A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers - Thorstensson, Rigmor; Trollfors, Birger; Al-Tawil, Nabil; Jahnmatz, Maja; Bergström, Jakob; Ljungman, Margaretha; Törner, Anna; Wehlin, Lena; Van Broekhoven, Annie; Bosman, Fons; Debrie, Anne-Sophie; Mielcarek, Nathalie; et al. (PloS one, 2014)
Keywords: Administration, Intranasal; Adult; Adults; Antigens; Attenuation; Bacteria; Biology; Bordetella pertussis; Bordetella pertussis - immunology; Bordetella pertussis - isolation & purification; Clinical trials; Colonization; Colony Count, Microbial; Demography; Disease control; Dosage; Dose-Response Relationship, Immunologic; Double-Blind Method; Double-blind studies; Genetic modification; Genetically modified organisms; Healthy Volunteers; Humans; Immune response; Immunity - immunology; Immunoglobulin G - blood; Infants; Infections; Influenza; Male; Medical research; Medicine; Nasopharynx; Nasopharynx - microbiology; Nasopharynx - pathology; Optimization; Pertussis; Pertussis Vaccine - adverse effects; Pertussis Vaccine - immunology; Pertussis Vaccine - therapeutic use; Placebos; Respiratory tract; Toxins; Vaccination; Vaccines; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Vaccines, Attenuated - therapeutic use; Whooping cough; Whooping Cough - blood; Whooping Cough - immunology; Whooping Cough - microbiology; Whooping Cough - prevention & control; Young Adult; France; Sweden