Transcription factor induced conversion of human fibroblasts towards the hair cell lineage

• Published in: PloS one Vol. 13; no. 7; p. e0200210
• Main Authors: Duran Alonso, María Beatriz, Lopez Hernandez, Iris, de la Fuente, Miguel Angel, Garcia-Sancho, Javier, Giraldez, Fernando, Schimmang, Thomas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.07.2018; Public Library of Science (PLoS)
• Subjects: Acoustics; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biology and Life Sciences; Biomarkers - metabolism; Brain; Cardiomyocytes; Cell lineage; Cell Lineage - drug effects; Cell Lineage - genetics; Cell Lineage - physiology; Cell Transdifferentiation - drug effects; Cell Transdifferentiation - genetics; Cell Transdifferentiation - physiology; Cells (biology); Cells, Cultured; Cochlea; Cèl·lules acústiques; Direct conversion; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Embryo cells; Embryonic stem cells; Epidermal Growth Factor - pharmacology; Epigenetics; Fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene expression; Gene Expression - drug effects; Genes; Hair; Hair cells; Hair Cells, Auditory - cytology; Hair Cells, Auditory - drug effects; Hair Cells, Auditory - metabolism; Hearing loss; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Inhibitory postsynaptic potentials; Mammals; Math1 protein; Mechanoreceptors; Medicine and Health Sciences; Myosin VIIa; Myosins - genetics; Nanoparticles; Neonates; Pluripotency; Progenitor cells; Receptors; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Regeneration; Research and Analysis Methods; Restoration; Risk factors; RNA, Messenger - genetics; RNA, Messenger - metabolism; Somatic cells; Stem cells; Transcription activation; Transcription Factor Brn-3C - genetics; Transcription Factor Brn-3C - metabolism; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Tretinoin - pharmacology; United States > US; Grand Island New York; Spain

Hearing loss is the most common sensorineural disorder, affecting over 5% of the population worldwide. Its most frequent cause is the loss of hair cells (HCs), the mechanosensory receptors of the cochlea. HCs transduce incoming sounds into electrical signals that activate auditory neurons, which in...