Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

• Published in: PLoS genetics Vol. 6; no. 10; p. e1001177
• Main Authors: Padmanabhan, Sandosh, Melander, Olle, Johnson, Toby, Di Blasio, Anna Maria, Lee, Wai K., Gentilini, Davide, Hastie, Claire E., Menni, Cristina, Monti, Maria Cristina, Delles, Christian, Laing, Stewart, Corso, Barbara, Navis, Gerjan, Kwakernaak, Arjan J., van der Harst, Pim, Bochud, Murielle, Maillard, Marc, Burnier, Michel, Hedner, Thomas, Kjeldsen, Sverre, Wahlstrand, Björn, Sjögren, Marketa, Fava, Cristiano, Montagnana, Martina, Danese, Elisa, Torffvit, Ole, Hedblad, Bo, Snieder, Harold, Connell, John M. C., Brown, Morris, Samani, Nilesh J., Farrall, Martin, Cesana, Giancarlo, Mancia, Giuseppe, Signorini, Stefano, Grassi, Guido, Eyheramendy, Susana, Wichmann, H. Erich, Laan, Maris, Strachan, David P., Sever, Peter, Shields, Denis Colm, Stanton, Alice, Vollenweider, Peter, Teumer, Alexander, Völzke, Henry, Rettig, Rainer, Newton-Cheh, Christopher, Arora, Pankaj, Zhang, Feng, Soranzo, Nicole, Spector, Timothy D., Lucas, Gavin, Kathiresan, Sekar, Siscovick, David S., Luan, Jian'an, Loos, Ruth J. F., Wareham, Nicholas J., Penninx, Brenda W., Nolte, Ilja M., McBride, Martin, Miller, William H., Nicklin, Stuart A., Baker, Andrew H., Graham, Delyth, McDonald, Robert A., Pell, Jill P., Sattar, Naveed, Welsh, Paul, Munroe, Patricia, Caulfield, Mark J., Zanchetti, Alberto, Dominiczak, Anna F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.10.2010; Public Library of Science (PLoS)
• Subjects: Age; Aged; Alleles; Blood Pressure; Body mass index; burden; Cardiac and Cardiovascular Systems; Cardiology and Cardiovascular Disease; Cardiovascular Disorders/Hypertension; Chromosomes, Human, Pair 16 - genetics; chronic kidney-disease; Clinical Medicine; Confidence intervals; feasibility; Female; Gene Frequency; Genetic Predisposition to Disease; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genome-Wide Association Study - methods; Genome-Wide Association Study - statistics & numerical data; Genomes; Genotype; Glomerular Filtration Rate; Health risk assessment; Heart attacks; Humans; Hypertension - genetics; Hypertension - physiopathology; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Linear Models; loci; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Meta-Analysis as Topic; Middle Aged; Mortality; Multivariate Analysis; mutations; nephropathy; Polymorphism, Single Nucleotide; Population; Proportional Hazards Models; Risk assessment; Risk Factors; Studies; Survival Analysis; tamm-horsfall protein; urinary-excretion; Uromodulin - blood; Uromodulin - genetics

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conduc...