Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model

• Published in: PloS one Vol. 8; no. 11; p. e80723
• Main Authors: Everitt, Aaron R, Clare, Simon, McDonald, Jacqueline U, Kane, Leanne, Harcourt, Katherine, Ahras, Malika, Lall, Amar, Hale, Christine, Rodgers, Angela, Young, Douglas B, Haque, Ashraful, Billker, Oliver, Tregoning, John S, Dougan, Gordon, Kellam, Paul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2013; Public Library of Science (PLoS)
• Subjects: Animal; Animals; Antiviral activity; Bacteria; Bacteria - metabolism; Biological response modifiers; Citrobacter; Citrobacter rodentium - growth & development; Citrobacter rodentium - physiology; Citrobacter rodentium/growth & development/physiology; College campuses; Disease control; Ethics; Gene expression; Genetic aspects; Genomes; Health aspects; Homeostasis; Immunology; In vivo methods and tests; Inbred C57BL; Infection; Infections; Infectious diseases; Influenza; Influenza viruses; Interferon; Kinetics; Knockout; Laboratories; Malaria - parasitology; Medical research; Membrane Proteins - deficiency; Membrane Proteins - metabolism; Membrane Proteins/deficiency/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Mycobacterium tuberculosis - growth & development; Mycobacterium tuberculosis - physiology; Mycobacterium tuberculosis/growth & development/physiology; Pathogenesis; Pathogenic microorganisms; Pathogens; Phenotype; Plasmodium berghei; Plasmodium berghei - growth & development; Plasmodium berghei - physiology; Plasmodium berghei/growth & development/physiology; Proteins; Protozoa; Respiratory syncytial virus; Respiratory Syncytial Viruses - growth & development; Respiratory Syncytial Viruses - physiology; Respiratory Syncytial Viruses/growth & development/physiology; Salmonella; Salmonella typhimurium - physiology; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Tuberculosis; Viral infections; Virology; Viruses; United Kingdom > UK

The interferon-inducible transmembrane (IFITM) family of proteins has been shown to restrict a broad range of viruses in vitro and in vivo by halting progress through the late endosomal pathway. Further, single nucleotide polymorphisms (SNPs) in its sequence have been linked with risk of developing...