Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects

• Published in: PloS one Vol. 7; no. 8; p. e42550
• Main Authors: Ottestad, Inger, Hassani, Sahar, Borge, Grethe I., Kohler, Achim, Vogt, Gjermund, Hyötyläinen, Tuulia, Orešič, Matej, Brønner, Kirsti W., Holven, Kirsten B., Ulven, Stine M., Myhrstad, Mari C. W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2012; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Biology; Body mass; Body Mass Index; Cardiovascular disease; Chains; Cholesterol; Chromatography; Chromatography, Liquid - methods; Dietary Supplements; Double-Blind Method; Fatty acids; Fatty Acids, Unsaturated - blood; Female; Fish; Fish oils; Fish Oils - pharmacology; High density lipoprotein; Humans; Intervention; Ionization; Lecithin; Lipid metabolism; Lipids; Lipids - blood; Lipoproteins (high density); Lipoproteins (low density); Liquid chromatography; Low density lipoprotein; Lysophosphatidylcholine; Male; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Mathematics; Medicine; Metabolism; Middle Aged; Oils & fats; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylglycerol; Phosphatidylserine; Phospholipids; Phospholipids - blood; Physiological aspects; Plant Oils - pharmacology; Polyunsaturated fatty acids; Quadrupoles; Regression Analysis; Research Design; Sphingomyelin; Studies; Sunflower Oil; Supplementation; Triglycerides; Triglycerides - blood; Unsaturated fatty acids; Norway; Finland

While beneficial health effects of fish and fish oil consumption are well documented, the incorporation of n-3 polyunsaturated fatty acids in plasma lipid classes is not completely understood. The aim of this study was to investigate the effect of fish oil supplementation on the plasma lipidomic pro...