Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

• Published in: PLoS biology Vol. 17; no. 2; p. e3000064
• Main Authors: Sadier, Alexa, Twarogowska, Monika, Steklikova, Klara, Hayden, Luke, Lambert, Anne, Schneider, Pascal, Laudet, Vincent, Hovorakova, Maria, Calvez, Vincent, Pantalacci, Sophie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.02.2019; Public Library of Science (PLoS)
• Subjects: Activation; Animals; Bernard, Claude (1813-1878); Biochemistry, Molecular Biology; Biology and Life Sciences; Body Patterning; Cell aggregation; Chemotaxis; Development Biology; Developmental biology; Edar Receptor - genetics; Edar Receptor - metabolism; Embryogenesis; Embryology and Organogenesis; Embryonic growth stage; Epithelium - embryology; Epithelium - metabolism; Funding; Gene expression; Gene Expression Regulation, Developmental; Genetic aspects; Genomics; Hair; Hair - embryology; Insects; Life Sciences; Medicine and Health Sciences; Mice; Mice, Mutant Strains; Models, Biological; Molars; Morphogenesis; Observations; Pattern formation; Patterning; Premolars; Signal Transduction; Signaling; Supervision; Teeth; Tooth - embryology; Tooth - metabolism; Tooth Germ - embryology; Tooth Germ - metabolism; Los Angeles California; Czech Republic; California; France; United States > US; Jaw; Teeth; Molars; Signaling centers; Epithelium; Chemotaxis; Embryos; Embryonic pattern formation

When patterns are set during embryogenesis, it is expected that they are straightly established rather than subsequently modified. The patterning of the three mouse molars is, however, far from straight, likely as a result of mouse evolutionary history. The first-formed tooth signaling centers, call...