Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination

• Published in: PLoS biology Vol. 9; no. 10; p. e1001176
• Main Authors: Grey, Corinne, Barthès, Pauline, Chauveau-Le Friec, Gaëlle, Langa, Francina, Baudat, Frédéric, de Massy, Bernard
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2011; Public Library of Science (PLoS)
• Subjects: Animals; Artificial chromosomes; Biology; Crossing Over, Genetic; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; Experiments; Fingers & toes; Genetic diversity; Genetic engineering; Genetic recombination; Genetics; Genomes; Histone-Lysine N-Methyltransferase - genetics; Histones - metabolism; Life Sciences; Meiosis; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Zinc Fingers; Zinc Fingers; Animals; Crossing Over, Genetic; Histone-Lysine N-Methyltransferase; Mice, Inbred C57BL; Histones; Mice, Transgenic; Meiosis; Mice; Methylation; DNA Breaks, Double-Stranded

Meiotic recombination generates reciprocal exchanges between homologous chromosomes (also called crossovers, COs) that are essential for proper chromosome segregation during meiosis and are a major source of genome diversity by generating new allele combinations. COs have two striking properties: th...