Architecture of a channel-forming O-antigen polysaccharide ABC transporter

• Published in: Nature (London) Vol. 553; no. 7688; pp. 361 - 365
• Main Authors: Bi, Yunchen, Mann, Evan, Whitfield, Chris, Zimmer, Jochen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.01.2018; Nature Publishing Group
• Subjects: 631/326/421; 631/535/1266; 631/57/2270; ABC transporter; ABC transporters; Adenosine triphosphate; Antigens; Binding; Biosynthesis; Cell surface; Cellulose; Chemical properties; Chemical synthesis; Conformation; Crystal structure; E coli; Health aspects; Helices; Homology; Humanities and Social Sciences; Immune response; Innate immunity; Interfaces; Klebsiella pneumoniae; letter; Lipid A; Lipids; Lipopolysaccharides; multidisciplinary; Periplasm; Physiological aspects; Polymers; Polysaccharides; Proteins; Saccharides; Science; Site-directed mutagenesis; Structure-function relationships; Substrates; Translocation; Transport; Transport proteins; United States

The crystal structure of a channel-forming O-antigen polysaccharide ABC transporter suggests a novel biopolymer translocation mechanism. Structure of an O-antigen polysaccharide transporter Bacterial cells are decorated with polysaccharides such as O-antigens, which help them to evade the innate imm...