Impact of Environmental Chemicals on Lung Development

• Published in: Environmental health perspectives Vol. 118; no. 8; pp. 1155 - 1164
• Main Authors: Miller, Mark D., Marty, Melanie A.
• Format: Journal Article
• Language: English
• Published: Research Triangle Park, NC National Institute of Environmental Health Sciences 01.08.2010; US Department of Health and Human Services
• Subjects: Adults; Alterations; Animals; Arsenic; Asthma; Biological and medical sciences; Biological effects; Cellular signal transduction; Chemical hazards; Chemicals; Developmental biology; Disruption; Environment. Living conditions; Environmental aspects; Environmental assessment; Environmental health; Environmental impact; Environmental Pollutants - toxicity; Epidemiology; Epithelial cells; Exposure; Fetal Development - drug effects; Growth factors; Health aspects; Humans; Lung - drug effects; Lung - embryology; Lung - pathology; Lung diseases; Lungs; Macaca mulatta; Medical sciences; Mice; Morphogenesis; Morphogenesis - drug effects; Nicotine - toxicity; Ozone - toxicity; Pesticides - toxicity; Phthalic Acids - toxicity; Public health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Pulmonary alveoli; Rats; Respiratory function; Review; Reviews; Risk assessment; Risk factors; Toxicology; Xenobiotics; Xenobiotics - toxicity; United States; Human; Lung disease; developmental toxicology; risk assessment; Respiratory disease; Lung; Risk; children's environmental health; Chemical product; Signal transduction; Toxicology; Health policy; Health and environment; Sciences; Risk factor; cell signaling; Development; Environment; science policy; Child; Public health; lung development

Background: Disruption of fundamental biologic processes and associated signaling events may result in clinically significant alterations in lung development. Objectives: We reviewed evidence on the impact of environmental chemicals on lung development and key signaling events in lung morphogenesis,...