Abstract 1714: The role of Hedgehog signaling in the regulation of human colon cancer stem cells

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 1714
• Main Authors: Regan, Joseph L., Staudte, Stephanie, Schumacher, Dirk, Keilholz, Ulrich, Haybaeck, Johannes, Lehrach, Hans, Yaspo, Marie-Laure, Henderson, David, Steffen, Andreas, Toedling, Joern, Lesche, Ralf, Schaefer, Reinhold, Regenbrecht, Christian R., Mumberg, Dominik, Lange, Martin
• Format: Journal Article
• Language: English
• Published: 15.07.2016

Abstract Recent data support a hierarchical model of colon cancer in which tumor growth is driven by a subpopulation of cancer stem cells (CSCs) that may also be the source of relapse following treatment. Elucidation of the cellular heterogeneity within a tumor would therefore facilitate better char...