Twist: A Regulator of Epithelial-Mesenchymal Transition in Lung Fibrosis

• Published in: PloS one Vol. 4; no. 10; p. e7559
• Main Authors: Pozharskaya, Veronika, Torres-González, Edilson, Rojas, Mauricio, Gal, Anthony, Amin, Minal, Dollard, Sheila, Roman, Jesse, Stecenko, Arlene A., Mora, Ana L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.10.2009; Public Library of Science (PLoS)
• Subjects: Alveoli; Analysis; Angiogenesis; Animals; Apoptosis; Breast cancer; Cadherins - metabolism; Cell Biology; Cell injury; Chronic infection; Critical care; Cystic fibrosis; Cytomegalovirus; Deoxyribonucleic acid; DNA; E-cadherin; Epithelial cells; Epithelial Cells - metabolism; Epithelium - metabolism; Epstein-Barr virus; Fibroblasts; Fibrosis; Gene expression; Gene Expression Regulation; Growth factors; Health aspects; Hepatitis; Herpes viruses; Herpesviridae - metabolism; Herpesviridae Infections - virology; Herpesvirus; Humans; Immunization; Immunology; In vitro methods and tests; Infection; Infections; Injuries; Lung - metabolism; Lung - pathology; Lung diseases; Lungs; Medical research; Medicine; Mesenchyme; Mesoderm - metabolism; Mice; N-Cadherin; Nuclear Proteins - metabolism; Pathogenesis; Pediatrics; Preservation; Proteins; Pulmonary Alveoli - metabolism; Pulmonary fibrosis; Pulmonary Fibrosis - pathology; Respiratory diseases; Respiratory Medicine/Interstitial Lung Diseases; Respiratory Medicine/Respiratory Infections; Stem cells; Transcription factors; Twist protein; Twist-Related Protein 1 - metabolism; Viral infections; Virus diseases; Viruses; Atlanta Georgia; United States > US; Georgia

Several studies have implicated viral infection as an important factor in the pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to cause epithelial cell injury and promote epithelial-mesenchymal transition (EMT), a process whereby differentiated epithelial cells undergo tr...