Angiotensin II facilitates breast cancer cell migration and metastasis

• Published in: PloS one Vol. 7; no. 4; p. e35667
• Main Authors: Rodrigues-Ferreira, Sylvie, Abdelkarim, Mohamed, Dillenburg-Pilla, Patricia, Luissint, Anny-Claude, di-Tommaso, Anne, Deshayes, Frédérique, Pontes, Carmen Lucia S, Molina, Angie, Cagnard, Nicolas, Letourneur, Franck, Morel, Marina, Reis, Rosana I, Casarini, Dulce E, Terris, Benoit, Couraud, Pierre-Olivier, Costa-Neto, Claudio M, Di Benedetto, Mélanie, Nahmias, Clara
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.04.2012; Public Library of Science (PLoS)
• Subjects: Adhesion; Angiogenesis; Angiotensin; Angiotensin II; Angiotensin II - physiology; Angiotensinogen; Angiotensins; Animals; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Biochemistry; Biology; Bone Neoplasms - secondary; Brain Neoplasms - secondary; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cancer metastasis; Cell adhesion; Cell adhesion & migration; Cell Adhesion - genetics; Cell Line, Tumor; Cell migration; Cell Proliferation; Cloning; Coculture Techniques; Collaboration; Colonization; Deoxyribonucleic acid; Development and progression; DNA; DNA microarrays; Endothelial cells; Endothelium; Enzymes; Extracellular matrix; Extravasation; Female; Gelatinase A; Gelatinase B; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genes; Hostages; Humans; Immunology; Intercellular adhesion molecule 1; Invasiveness; Kinases; Life Sciences; Lung Neoplasms - secondary; Malignancy; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Medical prognosis; Medicine; Meta-analysis; Metastases; Metastasis; Mice; Mice, Nude; Neoplasm Transplantation; Organs; Transendothelial and Transepithelial Migration - genetics; Tumor cells; Tumors; Vasoactive agents; France

Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps of cancer metastasis, i.e. extravasation of circulating tumor cells and colonization of secondary organs. In this study, we investigated wheth...