Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana

• Published in: PLoS genetics Vol. 8; no. 11; p. e1003062
• Main Authors: Deleris, Angelique, Stroud, Hume, Bernatavichute, Yana, Johnson, Elizabeth, Klein, Gregor, Schubert, Daniel, Jacobsen, Steven E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2012; Public Library of Science (PLoS)
• Subjects: Arabidopsis - genetics; Arabidopsis - metabolism; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; Biology; Deoxyribonucleic acid; DNA; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methylation; DNA Transposable Elements - genetics; Epigenesis, Genetic; Gene expression; Gene Expression Regulation, Plant; Genes; Genetic aspects; Genetics; Health aspects; Heterochromatin - genetics; Histone-Lysine N-Methyltransferase; Histones - genetics; Interspersed Repetitive Sequences; Jumonji Domain-Containing Histone Demethylases - genetics; Jumonji Domain-Containing Histone Demethylases - metabolism; Lysine - genetics; Methylation; Methyltransferases; Physiological aspects; Plant genetics; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Proteins; Transposons; France

Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein-coding genes, whil...