Cardiac Molecular-Acclimation Mechanisms in Response to Swimming-Induced Exercise in Atlantic Salmon

• Published in: PloS one Vol. 8; no. 1; p. e55056
• Main Authors: Castro, Vicente, Grisdale-Helland, Barbara, Helland, Ståle J., Torgersen, Jacob, Kristensen, Torstein, Claireaux, Guy, Farrell, Anthony P., Takle, Harald
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.01.2013; Public Library of Science (PLoS)
• Subjects: Acclimation; Acclimatization; Agriculture; Animals; Biology; Cardiac muscle; Cardiac output; Cardiomyocytes; Coupling (molecular); Cyclooxygenase-2; Cytokines - metabolism; Energy Metabolism; Enlargement; Environmental Sciences; Erythropoietin; Fish; Fishes; Gene expression; Gene regulation; Genes; Heart; Heart - physiology; Heart diseases; Hyperplasia; Hypertrophy; Immunofluorescence; Inflammation; Inflammation Mediators - metabolism; Interleukin 1; Interleukin 1 receptor antagonist; Kinases; Lipid peroxidation; Mammals; Metabolism; Mitochondria; Mitochondria - metabolism; Molecular modelling; Muscle contraction; Muscles; Myocardial Contraction; Myocardium - metabolism; Myocytes; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; NF-κB protein; Oncorhynchus mykiss; Oxidation; Oxygen; Oxygen Consumption; Physical Conditioning, Animal; Physical training; Physiological aspects; Proliferating cell nuclear antigen; Proteins; RNA; Salmo salar; Salmo salar - metabolism; Salmon; Salmonidae; Seafood industry; Swimming; Training; Transcription; Transcription (Genetics); Tumor necrosis factor; Vascular endothelial growth factor; Zebrafish; Norway

Cardiac muscle is a principal target organ for exercise-induced acclimation mechanisms in fish and mammals, given that sustained aerobic exercise training improves cardiac output. Yet, the molecular mechanisms underlying such cardiac acclimation have been scarcely investigated in teleosts. Consequen...