Systemic Inflammation, Nutritional Status and Tumor Immune Microenvironment Determine Outcome of Resected Non-Small Cell Lung Cancer

• Published in: PloS one Vol. 9; no. 9; p. e106914
• Main Authors: Alifano, Marco, Mansuet-Lupo, Audrey, Lococo, Filippo, Roche, Nicolas, Bobbio, Antonio, Canny, Emelyne, Schussler, Olivier, Dermine, Hervé, Régnard, Jean-François, Burroni, Barbara, Goc, Jérémy, Biton, Jérôme, Ouakrim, Hanane, Cremer, Isabelle, Dieu-Nosjean, Marie-Caroline, Damotte, Diane
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.09.2014; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma; Analysis; C-reactive protein; C-Reactive Protein - metabolism; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Care and treatment; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell survival; Chemotherapy; Chronic obstructive pulmonary disease; Cytokines; Dendritic cells; Determinants; Human health and pathology; Infiltration; Inflammation; Karnofsky Performance Status; Laboratories; Life Sciences; Lung cancer; Lung diseases; Lymphocytes; Medical prognosis; Medicine and Health Sciences; Metastases; Metastasis; Multivariate Analysis; Neoplasm Grading; Non-small cell lung cancer; Non-small cell lung carcinoma; Nutrition; Nutritional Status; Pathology; Patients; Prealbumin - metabolism; Prognosis; Radiation therapy; Retrospective Studies; Risk analysis; Statistical analysis; Studies; Surgery; Survival; Survival Analysis; Thoracic surgery; Tumor Microenvironment; Tumors

Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the purpose of this study was to assess their respective impact on long-term survival in resected non-small cell lung cancers (NSCLC). Clinical, path...