A hominoid-specific endogenous retrovirus may have rewired the gene regulatory network shared between primordial germ cells and naïve pluripotent cells

• Published in: PLoS genetics Vol. 18; no. 5; p. e1009846
• Main Authors: Ito, Jumpei, Seita, Yasunari, Kojima, Shohei, Parrish, Nicholas F., Sasaki, Kotaro, Sato, Kei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.05.2022; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Epigenetics; Evolution; Gene expression; Genetic aspects; Genetic regulation; Genomes; Germ cells; KLF4 protein; Physiological aspects; Pluripotency; Retroviruses; Stem cells; Transcription factors; Transcriptomes; Japan

Mammalian germ cells stem from primordial germ cells (PGCs). Although the gene regulatory network controlling the development of germ cells such as PGCs is critical for ensuring gamete integrity, substantial differences exist in this network among mammalian species, suggesting that this network has...