Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene

• Published in: PLoS genetics Vol. 8; no. 7; p. e1002824
• Main Authors: Himes, Blanca E., Jiang, Xiaofeng, Hu, Ruoxi, Wu, Ann C., Lasky-Su, Jessica A., Klanderman, Barbara J., Ziniti, John, Senter-Sylvia, Jody, Lima, John J., Irvin, Charles G., Peters, Stephen P., Meyers, Deborah A., Bleecker, Eugene R., Kubo, Michiaki, Tamari, Mayumi, Nakamura, Yusuke, Szefler, Stanley J., Lemanske, Robert F., Zeiger, Robert S., Strunk, Robert C., Martinez, Fernando D., Hanrahan, John P., Koppelman, Gerard H., Postma, Dirkje S., Nieuwenhuis, Maartje A. E., Vonk, Judith M., Panettieri, Reynold A., Markezich, Amy, Israel, Elliot, Carey, Vincent J., Tantisira, Kelan G., Litonjua, Augusto A., Lu, Quan, Weiss, Scott T.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2012; Public Library of Science (PLoS)
• Subjects: Adolescent; Adrenergic beta-2 Receptor Agonists - administration & dosage; Adult; Aged; Aged, 80 and over; Airway management; Airway Obstruction - pathology; Asthma; Asthma - drug therapy; Asthma - genetics; Biology; Biomarkers, Pharmacological; Bronchi - metabolism; Bronchi - pathology; Bronchodilator Agents - administration & dosage; Child, Preschool; Clinical trials; Clinical Trials as Topic; Development and progression; Experiments; Female; Genes; Genetic aspects; Genetic polymorphisms; Genetics; Genome-Wide Association Study; Genomes; Genomics; Humans; Kinases; Male; Medicine; Middle Aged; Muscular system; Myocytes, Smooth Muscle - metabolism; Phenotype; Physiological aspects; Polymorphism, Single Nucleotide; Proteins - genetics; Smooth muscle; United States

Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration of a short-acting β(2)-agonist, the most common rescue medications used for the treatment of asthma. BDR also...