Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes

• Published in: PLoS genetics Vol. 8; no. 8; p. e1002834
• Main Authors: Wuttke, Daniel, Connor, Richard, Vora, Chintan, Craig, Thomas, Li, Yang, Wood, Shona, Vasieva, Olga, Shmookler Reis, Robert, Tang, Fusheng, de Magalhães, João Pedro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2012; Public Library of Science (PLoS)
• Subjects: Aging; Aging - genetics; Animals; Biological Evolution; Biology; Caloric Restriction; Databases, Genetic; Diet; Gametogenesis - genetics; Gene expression; Gene Regulatory Networks; Genes, Essential; Genetic aspects; Genomics; Health aspects; Humans; Kinases; Life Expectancy; Longevity; Longevity - genetics; Medical research; Mutation; Physiological aspects; Proteins; Saccharomyces cerevisiae; Systems Biology - methods; United Kingdom

Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests the involvement of fundamental mechanisms, although these remain a subject of debate. To...