Characterization and Clinical Impact of Bloodstream Infection Caused by Carbapenemase-Producing Enterobacteriaceae in Seven Latin American Countries

• Published in: PloS one Vol. 11; no. 4; p. e0154092
• Main Authors: Villegas, Maria Virginia, Pallares, Christian J., Escandón-Vargas, Kevin, Hernández-Gómez, Cristhian, Correa, Adriana, Álvarez, Carlos, Rosso, Fernando, Matta, Lorena, Luna, Carlos, Zurita, Jeannete, Mejía-Villatoro, Carlos, Rodríguez-Noriega, Eduardo, Seas, Carlos, Cortesía, Manuel, Guzmán-Suárez, Alfonso, Guzmán-Blanco, Manuel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.04.2016; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Automation; Bacterial Proteins - biosynthesis; beta-Lactamases - biosynthesis; Biology and Life Sciences; Carbapenemase; Child; Child, Preschool; Colistin; Confidence intervals; Data collection; Demographics; Development and progression; Drug resistance; Economic aspects; Enterobacteriaceae; Enterobacteriaceae - drug effects; Enterobacteriaceae infections; Enterobacteriaceae Infections - drug therapy; Enterobacteriaceae Infections - epidemiology; Enterobacteriaceae Infections - physiopathology; Fatalities; Female; Gram-negative bacteria; Health care; Health risks; Hospitals; Humans; Infant; Infant, Newborn; Infections; Intensive care; Klebsiella pneumoniae; Latin America - epidemiology; Male; Medical laboratories; Medical records; Medical research; Medicine and Health Sciences; Microbial Sensitivity Tests; Middle Aged; Mortality; Mortality risk; Observational studies; Patients; People and Places; Physiological aspects; Polymerase chain reaction; Polymyxin B; Public health; Risk analysis; Risk factors; Sepsis - drug therapy; Sepsis - epidemiology; Sepsis - microbiology; Sepsis - physiopathology; Studies; Surveillance; Therapy; Tigecycline; Young Adult; Colombia; Venezuela; Greece; Ecuador; Argentina; United States > US; Guatemala; Mexico; Israel; Peru

Infections caused by carbapenem-resistant Enterobacteriaceae are a public health problem associated with higher mortality rates, longer hospitalization and increased healthcare costs. We carried out a study to describe the characteristics of patients with carbapenemase-producing Enterobacteriaceae (...