In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome

• Published in: PloS one Vol. 11; no. 6; p. e0156952
• Main Authors: Bakshi, Mayur V, Azimzadeh, Omid, Merl-Pham, Juliane, Verreet, Tine, Hauck, Stefanie M, Benotmane, Mohammed A, Atkinson, Michael J, Tapio, Soile
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2016; Public Library of Science (PLoS)
• Subjects: Animals; Antiviral agents; Atherosclerosis; Bioinformatics; Biology; Biology and Life Sciences; Cardiomyopathy; Cardiovascular disease; Cardiovascular diseases; Cytoskeleton; Data processing; Embryogenesis; Embryonic development; Embryonic growth stage; Environmental health; Exposure; Female; Females; Fetuses; Heart; Heart diseases; Heat shock; Immunoblotting; Ionizing radiation; Irradiation; Kinases; Laboratories; Light; Male; Mass spectrometry; Mass spectroscopy; Maternal Exposure - adverse effects; Medicine and Health Sciences; Mice; Mitochondria; Molecular chains; Molecular modelling; Muscle Proteins - biosynthesis; Myocardium - metabolism; Neurosciences; Nuclear physics; Offspring; Oxygen; Physical Sciences; Physiological aspects; Pregnancy; Prenatal experience; Prenatal exposure; Prenatal Exposure Delayed Effects - metabolism; Proteins; Proteome - biosynthesis; Proteomics; Radiation; Radiation dosage; Radiation effects; Radiation Injuries, Experimental - metabolism; Reactive oxygen species; Research and Analysis Methods; Risk factors; X-Rays - adverse effects; Belgium; Germany

Prenatal exposure to stress such as increased level of reactive oxygen species or antiviral therapy are known factors leading to adult heart defects. The risks following a radiation exposure during fetal period are unknown, as are the mechanisms of any potential cardiac damage. The aim of this study...