The Role of Reactive Oxygen Species in Antibiotic-Induced Cell Death in Burkholderia cepacia Complex Bacteria

• Published in: PloS one Vol. 11; no. 7; p. e0159837
• Main Authors: Van Acker, Heleen, Gielis, Jan, Acke, Marloes, Cools, Freya, Cos, Paul, Coenye, Tom
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.07.2016; Public Library of Science (PLoS)
• Subjects: Analysis; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Antibiotics; Antioxidants; Apoptosis; Bacteria; Biofilms; Biofilms - drug effects; Biofilms - growth & development; Biology and Life Sciences; Burkholderia cenocepacia; Burkholderia cepacia; Burkholderia cepacia complex - drug effects; Burkholderia cepacia complex - growth & development; Burkholderia cepacia complex - metabolism; Burkholderia Infections - drug therapy; Burkholderia Infections - metabolism; Burkholderia Infections - microbiology; Carbonyls; Cell death; Cell Death - drug effects; Ciprofloxacin; Ciprofloxacin - pharmacology; Deoxyribonucleic acid; DNA; DNA damage; E coli; Electron paramagnetic resonance; Enzymes; Escherichia coli; Free radicals; Gene expression; Gene Expression Regulation, Bacterial - drug effects; Hydrogen peroxide; Hydroxyl radicals; Hygiene; Laboratories; Medicine and Health Sciences; Meropenem; Microbial Sensitivity Tests; Oxidation; Oxidative stress; Oxygen; Parasitology; Pharmaceuticals; Physical Sciences; Physiological aspects; Proteins; Pseudomonas aeruginosa; Reactive oxygen species; Reactive Oxygen Species - metabolism; Repressor Proteins - biosynthesis; Research and Analysis Methods; Respiration; Spectrophotometry; Streptococcus infections; Thienamycins - pharmacology; Thoracic surgery; Tobramycin; Tobramycin - pharmacology; Belgium
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0159837

It was recently proposed that bactericidal antibiotics, besides through specific drug-target interactions, kill bacteria by a common mechanism involving the production of reactive oxygen species (ROS). However, this mechanism involving the production of hydroxyl radicals has become the subject of a...