Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds

• Published in: PloS one Vol. 11; no. 4; p. e0153649
• Main Authors: Matsuu, Aya, Kobayashi, Tomoko, Patchimasiri, Tuangthong, Shiina, Takashi, Suzuki, Shingo, Chaichoune, Kridsada, Ratanakorn, Parntep, Hiromoto, Yasuaki, Abe, Haruka, Parchariyanon, Sujira, Saito, Takehiko
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.04.2016; Public Library of Science (PLoS)
• Subjects: Analysis; Animal tissues; Animals; Avian flu; Avian influenza; Avian influenza virus; Avian Proteins - genetics; Biology and Life Sciences; Brain; Breeding; Chickens; Chickens - classification; Chickens - genetics; Chickens - virology; Cytokines - genetics; Epidemics; Genetic aspects; Genetic polymorphisms; Health aspects; Host Specificity; Humans; Inflammation; Influenza; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza in Birds - genetics; Influenza in Birds - virology; Interleukin 6; Kinases; Lethality; Lungs; Major histocompatibility complex; Medicine and health sciences; Molecular Sequence Data; Pandemics; Pathogenicity; Pathogens; People and Places; Poultry; Replication; Research and Analysis Methods; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Species Specificity; Spleen; Viral proteins; Virulence; Virus Replication; Virus Shedding; Viruses; Thailand; Southeast Asia; China; Japan; Africa; Bangkok Thailand

Differences in the pathogenicity of genetically closely related H5N1 highly pathogenic avian influenza viruses (HPAIVs) were evaluated in White Leghorn chickens. These viruses varied in the clinical symptoms they induced, including lethality, virus shedding, and replication in host tissues. A compar...