Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages

• Published in: PloS one Vol. 12; no. 2; p. e0171358
• Main Authors: La Manna, Marco Pio, Orlando, Valentina, Dieli, Francesco, Di Carlo, Paola, Cascio, Antonio, Cuzzi, Gilda, Palmieri, Fabrizio, Goletti, Delia, Caccamo, Nadia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.02.2017; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Bacterial infections; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Biomedical research; Case-Control Studies; Child care; Confidence intervals; Diagnosis; Diagnostic software; Diagnostic systems; Female; Gene expression; Health promotion; HIV; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Laboratories; Lupus; Lymphocytes; Male; Medical diagnosis; Medicine and Health Sciences; Mens health; Middle Aged; Monocytes; Monocytes - metabolism; Monocytes - microbiology; Monocytes - pathology; Morbidity; Mycobacterium; Mycobacterium avium; Mycobacterium tuberculosis; Mycobacterium tuberculosis - pathogenicity; Patients; Peripheral blood; Phenotype; Risk factors; Sensitivity; Sensitivity analysis; Stem cells; Tuberculosis; Tuberculosis - blood; Tuberculosis - classification; Tuberculosis - diagnosis; Womens health; Young Adult; Italy

Tuberculosis (TB) is one of the most important cause of morbidity and death among infectious diseases, and continuous efforts are needed to improve diagnostic tools and therapy. Previous published studies showed that the absolute cells number of monocytes or lymphocytes in peripheral blood or yet th...