Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

• Published in: PloS one Vol. 7; no. 9; p. e44664
• Main Authors: Greenblatt, Matthew B., Vbranac, Vladimir, Tivey, Trevor, Tsang, Kelly, Tager, Andrew M., Aliprantis, Antonios O.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.09.2012; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Allografts; Analysis; Animal models; Animals; B cells; Biology; Bone marrow; Bone Marrow - pathology; Bone marrow transplantation; CD11b antigen; CD4 antigen; CD4-Positive T-Lymphocytes - cytology; Cytokines - metabolism; Disease Models, Animal; Fetuses; Gastrointestinal tract; Genetic analysis; Glands; Graft versus host disease; Graft vs Host Disease - etiology; Graft vs Host Disease - immunology; Graft-versus-host reaction; Histocompatibility antigen HLA; Histocompatibility Antigens Class I - metabolism; Histocompatibility Antigens Class II - metabolism; HIV; Human immunodeficiency virus; Humans; Immune system; Incidence; Infiltration; Inflammation; Interleukin 2; Interleukin-2 - metabolism; Laboratory animals; Laboratory tests; Liver; Liver - pathology; Lungs; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - metabolism; Major histocompatibility complex; Medicine; Mice; Mice, Inbred NOD; Mice, SCID; Phenotypes; Risk; Rodents; Scleroderma; Sclerosis; Skin; Skin - metabolism; Spleen - cytology; T cells; Thymus; Thymus Gland - pathology; Womens health; Xenografts; United States > US; Massachusetts; Germany

Mice bearing a "humanized" immune system are valuable tools to experimentally manipulate human cells in vivo and facilitate disease models not normally possible in laboratory animals. Here we describe a form of GVHD that develops in NOD/SCID mice reconstituted with human fetal bone marrow,...