MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer

• Published in: PloS one Vol. 12; no. 3; p. e0173912
• Main Authors: Bai, Lin, Wang, Hui, Wang, Ai-Hua, Zhang, Luo-Ying, Bai, Jie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.03.2017; Public Library of Science (PLoS)
• Subjects: 3' Untranslated regions; Analysis; Animals; Binding sites; Bioinformatics; Biology and life sciences; Cancer; Care and treatment; Cell proliferation; Cell Proliferation - genetics; Cell survival; Complementary DNA; Correlation analysis; Development and progression; Epigenetics; Female; Gastric cancer; Gene expression; Genetic aspects; Genetic regulation; Gynecology; Heterografts; Humans; Infrared imaging systems; Metastasis; Mice; Mice, Nude; MicroRNA; MicroRNAs; MicroRNAs - physiology; miRNA; Neoplasm Invasiveness; Obstetrics; Oligonucleotides; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - enzymology; Ovarian Neoplasms - pathology; Physiological aspects; Regulators; Research and Analysis Methods; Reverse transcriptase; Ribonucleic acid; RNA; RNA-directed DNA polymerase; siRNA; Stomach cancer; Survival Analysis; Telomerase; Telomerase reverse transcriptase; Tissues; Tumors; China

Human telomerase reverse transcriptase (hTERT) plays a crucial role in ovarian cancer (OC) progression. However, the mechanisms underlying hTERT upregulation in OC, and the specific microRNAs (miRNAs) involved in the regulation of hTERT in OC cells, remains unclear. We performed a bioinformatics sea...