Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines

• Published in: PloS one Vol. 11; no. 9; p. e0162574
• Main Authors: Hoshina, Shiho, Sekizuka, Tsuyoshi, Kataoka, Michiyo, Hasegawa, Hideki, Hamada, Hiromichi, Kuroda, Makoto, Katano, Harutaka
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.09.2016; Public Library of Science (PLoS)
• Subjects: Biology and life sciences; Biotechnology; Blotting, Western; Cell Line, Tumor; Comparative analysis; Deoxyribonucleic acid; DNA; Epstein-Barr virus; Exosomes; Exosomes - genetics; Exosomes - metabolism; Exosomes - ultrastructure; Exosomes - virology; Genomes; Genomics; Herpesviridae; Herpesviridae - genetics; Herpesvirus; High-Throughput Nucleotide Sequencing; Hostages; Humans; Infectious diseases; Intracellular; Kaposi's sarcoma-associated herpesvirus; Localization; Lymphoma; Lymphoma - genetics; Lymphoma - metabolism; Lymphoma - virology; Lymphomas; MicroRNA; MicroRNAs; MicroRNAs - genetics; Microscopy, Electron; miRNA; Pathogens; Pathology; Pediatrics; Polymerase Chain Reaction; Proteins; Research and Analysis Methods; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; Sarcoma; Tumor cell lines; Viruses; United States > US; Japan

Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exos...