Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines

Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exos...

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Published inPloS one Vol. 11; no. 9; p. e0162574
Main Authors Hoshina, Shiho, Sekizuka, Tsuyoshi, Kataoka, Michiyo, Hasegawa, Hideki, Hamada, Hiromichi, Kuroda, Makoto, Katano, Harutaka
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 09.09.2016
Public Library of Science (PLoS)
Subjects
Biology and life sciences
Biotechnology
Blotting, Western
Cell Line, Tumor
Comparative analysis
Deoxyribonucleic acid
DNA
Epstein-Barr virus
Exosomes
Exosomes - genetics
Exosomes - metabolism
Exosomes - ultrastructure
Exosomes - virology
Genomes
Genomics
Herpesviridae
Herpesviridae - genetics
Herpesvirus
High-Throughput Nucleotide Sequencing
Hostages
Humans
Infectious diseases
Intracellular
Kaposi's sarcoma-associated herpesvirus
Localization
Lymphoma
Lymphoma - genetics
Lymphoma - metabolism
Lymphoma - virology
Lymphomas
MicroRNA
MicroRNAs
MicroRNAs - genetics
Microscopy, Electron
miRNA
Pathogens
Pathology
Pediatrics
Polymerase Chain Reaction
Proteins
Research and Analysis Methods
Reverse Transcriptase Polymerase Chain Reaction
Ribonucleic acid
RNA
Sarcoma
Tumor cell lines
Viruses
United States > US
Japan
Online AccessGet full text

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Abstract Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exosomes. However, there is little information about the detailed distribution of virus-encoded miRNAs in cells and exosomes. In this study, we thus identified virus- and host-encoded miRNAs in exosomes released from KSHV- or EBV-infected lymphoma cell lines and compared them with intracellular miRNAs using a next-generation sequencer. Sequencing analysis demonstrated that 48% of the annotated miRNAs in the exosomes from KSHV-infected cells originated from KSHV. Human mir-10b-5p and mir-143-3p were much more highly concentrated in exosomes than in cells. Exosomes contained more nonexact mature miRNAs that did not exactly match those in miRBase than cells. Among the KSHV-encoded miRNAs, miRK12-3-5p was the most abundant exact mature miRNA in both cells and exosomes that exactly matched those in miRBase. Recently identified EXOmotifs, nucleotide motifs that control the loading of miRNAs into exosomes were frequently found within the sequences of KSHV-encoded miRNAs, and the presence of the EXOmotif CCCT or CCCG was associated with the localization of miRNA in exosomes in KSHV-infected cells. These observations suggest that specific virus-encoded miRNAs are sorted by EXOmotifs and accumulate in exosomes in virus-infected cells.
AbstractList Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exosomes. However, there is little information about the detailed distribution of virus-encoded miRNAs in cells and exosomes. In this study, we thus identified virus- and host-encoded miRNAs in exosomes released from KSHV- or EBV-infected lymphoma cell lines and compared them with intracellular miRNAs using a next-generation sequencer. Sequencing analysis demonstrated that 48% of the annotated miRNAs in the exosomes from KSHV-infected cells originated from KSHV. Human mir-10b-5p and mir-143-3p were much more highly concentrated in exosomes than in cells. Exosomes contained more nonexact mature miRNAs that did not exactly match those in miRBase than cells. Among the KSHV-encoded miRNAs, miRK12-3-5p was the most abundant exact mature miRNA in both cells and exosomes that exactly matched those in miRBase. Recently identified EXOmotifs, nucleotide motifs that control the loading of miRNAs into exosomes were frequently found within the sequences of KSHV-encoded miRNAs, and the presence of the EXOmotif CCCT or CCCG was associated with the localization of miRNA in exosomes in KSHV-infected cells. These observations suggest that specific virus-encoded miRNAs are sorted by EXOmotifs and accumulate in exosomes in virus-infected cells.
Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exosomes. However, there is little information about the detailed distribution of virus-encoded miRNAs in cells and exosomes. In this study, we thus identified virus- and host-encoded miRNAs in exosomes released from KSHV- or EBV-infected lymphoma cell lines and compared them with intracellular miRNAs using a next-generation sequencer. Sequencing analysis demonstrated that 48% of the annotated miRNAs in the exosomes from KSHV-infected cells originated from KSHV. Human mir-10b-5p and mir-143-3p were much more highly concentrated in exosomes than in cells. Exosomes contained more nonexact mature miRNAs that did not exactly match those in miRBase than cells. Among the KSHV-encoded miRNAs, miRK12-3-5p was the most abundant exact mature miRNA in both cells and exosomes that exactly matched those in miRBase. Recently identified EXOmotifs, nucleotide motifs that control the loading of miRNAs into exosomes were frequently found within the sequences of KSHV-encoded miRNAs, and the presence of the EXOmotif CCCT or CCCG was associated with the localization of miRNA in exosomes in KSHV-infected cells. These observations suggest that specific virus-encoded miRNAs are sorted by EXOmotifs and accumulate in exosomes in virus-infected cells.Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), encode miRNAs in their genomes and express virus-encoded miRNAs in cells and exosomes. However, there is little information about the detailed distribution of virus-encoded miRNAs in cells and exosomes. In this study, we thus identified virus- and host-encoded miRNAs in exosomes released from KSHV- or EBV-infected lymphoma cell lines and compared them with intracellular miRNAs using a next-generation sequencer. Sequencing analysis demonstrated that 48% of the annotated miRNAs in the exosomes from KSHV-infected cells originated from KSHV. Human mir-10b-5p and mir-143-3p were much more highly concentrated in exosomes than in cells. Exosomes contained more nonexact mature miRNAs that did not exactly match those in miRBase than cells. Among the KSHV-encoded miRNAs, miRK12-3-5p was the most abundant exact mature miRNA in both cells and exosomes that exactly matched those in miRBase. Recently identified EXOmotifs, nucleotide motifs that control the loading of miRNAs into exosomes were frequently found within the sequences of KSHV-encoded miRNAs, and the presence of the EXOmotif CCCT or CCCG was associated with the localization of miRNA in exosomes in KSHV-infected cells. These observations suggest that specific virus-encoded miRNAs are sorted by EXOmotifs and accumulate in exosomes in virus-infected cells.
Audience Academic
Author Kuroda, Makoto
Hamada, Hiromichi
Kataoka, Michiyo
Katano, Harutaka
Hoshina, Shiho
Sekizuka, Tsuyoshi
Hasegawa, Hideki
AuthorAffiliation 3 Department of Pediatrics, Yachiyo Medical Center, Tokyo Women’s Medical University, 477-96 Owada-Shinden, Yachiyo, Chiba 276-0046, Japan
2 Pathogen Genomic Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
1 Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
Keck School of Medicine of the University of Southern California, UNITED STATES
AuthorAffiliation_xml – name: 2 Pathogen Genomic Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
– name: 3 Department of Pediatrics, Yachiyo Medical Center, Tokyo Women’s Medical University, 477-96 Owada-Shinden, Yachiyo, Chiba 276-0046, Japan
– name: Keck School of Medicine of the University of Southern California, UNITED STATES
– name: 1 Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
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  surname: Hoshina
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  surname: Katano
  fullname: Katano, Harutaka
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27611973$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/1743-422X-7-271
10.1016/j.cell.2010.06.035
10.1038/nri855
10.1126/science.1096781
10.1038/nm0396-342
10.1097/01.LAB.0000035025.51772.2B
10.1016/j.jcv.2015.06.104
10.1038/nm.2753
10.1126/science.7997879
10.1002/(SICI)1096-9071(199908)58:4<394::AID-JMV12>3.0.CO;2-H
10.1111/j.1349-7006.1990.tb02561.x
10.1038/ng1793
10.1128/JVI.05100-11
10.1038/ni854
10.1128/JVI.03159-12
10.1074/jbc.M009641200
10.1371/journal.ppat.1001294
10.1101/gad.192351.112
10.1038/nmeth746
10.1186/s13027-016-0086-5
10.1073/pnas.1014194107
10.1038/ncomms3980
10.1038/ncb1596
10.1371/journal.ppat.1003484
10.1371/journal.pone.0099163
10.1073/pnas.0914843107
10.1126/science.1136235
10.1182/blood-2003-03-0871
10.1093/nar/gni178
10.1016/j.bbrc.2014.10.146
10.1182/blood.V74.5.1844.1844
10.1083/jcb.138.5.1077
10.1128/JVI.01528-10
ContentType Journal Article
Copyright COPYRIGHT 2016 Public Library of Science
2016 Hoshina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2016 Hoshina et al 2016 Hoshina et al
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Conceptualization: HK. Data curation: TS M. Kuroda HK. Formal analysis: SH TS M. Kuroda HK. Funding acquisition: H. Hasegawa M. Kuroda HK. Investigation: SH TS M. Kataoka M. Kuroda HK. Methodology: HK TS M. Kuroda. Resources: HK. Supervision: HK H. Hamada. Writing – original draft: SH HK. Writing – review & editing: H. Hasegawa H. Hamada.
Competing Interests: The authors have declared that no competing interests exist.
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References C Gourzones (ref25) 2010; 7
C Thery (ref33) 2002; 3
R Feederle (ref7) 2011; 85
DM Pegtel (ref10) 2010; 107
F Baran-Marszak (ref19) 2002; 82
G Wang (ref26) 2010; 142
HW Hwang (ref27) 2007; 315
C Thery (ref1) 2002; 2
S Pfeffer (ref5) 2005; 2
C Chen (ref29) 2005; 33
RM Johnstone (ref21) 1989; 74
PE Chugh (ref15) 2013; 9
R Renne (ref14) 1996; 2
S Pfeffer (ref4) 2004; 304
BR Cullen (ref3) 2006; 38
Y Chang (ref18) 1994; 266
R Amoroso (ref30) 2011; 85
K Ainger (ref28) 1997; 138
C D'Souza-Schorey (ref31) 2012; 26
H Peinado (ref32) 2012; 18
Z Liu (ref23) 2014; 455
H Uhara (ref17) 1990; 81
C Geminard (ref20) 2001; 276
A Rocca (ref24) 2015; 70
M Osawa (ref16) 2016; 11
W Ahmed (ref9) 2014; 9
R Feederle (ref6) 2011; 7
C Villarroya-Beltri (ref12) 2013; 4
A de Gassart (ref22) 2003; 102
H Choi (ref8) 2013; 87
H Katano (ref13) 1999; 58
CP Lai (ref34) 2012; 3
H Valadi (ref2) 2007; 9
DG Meckes Jr. (ref11) 2010; 107
17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9
21068248 - J Virol. 2011 Jan;85(2):996-1010
24356509 - Nat Commun. 2013;4:2980
20304794 - Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33
16314309 - Nucleic Acids Res. 2005 Nov 27;33(20):e179
7997879 - Science. 1994 Dec 16;266(5192):1865-9
12429807 - Lab Invest. 2002 Nov;82(11):1463-79
2790208 - Blood. 1989 Oct;74(5):1844-51
23678170 - J Virol. 2013 Jul;87(14):8135-44
25449270 - Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):218-22
27536332 - Infect Agent Cancer. 2016 Aug 17;11:37
2161814 - Jpn J Cancer Res. 1990 Mar;81(3):272-8
22754538 - Front Physiol. 2012 Jun 27;3:228
17204650 - Science. 2007 Jan 5;315(5808):97-100
23874201 - PLoS Pathog. 2013;9(7):e1003484
12426563 - Nat Immunol. 2002 Dec;3(12):1156-62
9281585 - J Cell Biol. 1997 Sep 8;138(5):1077-87
15782219 - Nat Methods. 2005 Apr;2(4):269-76
8612236 - Nat Med. 1996 Mar;2(3):342-6
20950422 - Virol J. 2010 Oct 15;7:271
12881314 - Blood. 2003 Dec 15;102(13):4336-44
21059916 - Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20370-5
21379335 - PLoS Pathog. 2011 Feb;7(2):e1001294
12154376 - Nat Rev Immunol. 2002 Aug;2(8):569-79
26305810 - J Clin Virol. 2015 Sep;70:1-6
10421407 - J Med Virol. 1999 Aug;58(4):394-401
21752900 - J Virol. 2011 Oct;85(19):9801-10
16736021 - Nat Genet. 2006 Jun;38 Suppl:S25-30
15118162 - Science. 2004 Apr 30;304(5671):734-6
22713869 - Genes Dev. 2012 Jun 15;26(12):1287-99
24896633 - PLoS One. 2014 Jun 04;9(6):e99163
22635005 - Nat Med. 2012 Jun;18(6):883-91
20691904 - Cell. 2010 Aug 6;142(3):456-67
11133993 - J Biol Chem. 2001 Mar 30;276(13):9910-6
References_xml – volume: 7
  start-page: 271
  year: 2010
  ident: ref25
  article-title: Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells
  publication-title: Virol J
  doi: 10.1186/1743-422X-7-271
– volume: 142
  start-page: 456
  year: 2010
  ident: ref26
  article-title: PNPASE regulates RNA import into mitochondria
  publication-title: Cell
  doi: 10.1016/j.cell.2010.06.035
– volume: 2
  start-page: 569
  year: 2002
  ident: ref1
  article-title: Exosomes: composition, biogenesis and function
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri855
– volume: 304
  start-page: 734
  year: 2004
  ident: ref4
  article-title: Identification of virus-encoded microRNAs
  publication-title: Science
  doi: 10.1126/science.1096781
– volume: 2
  start-page: 342
  year: 1996
  ident: ref14
  article-title: Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
  publication-title: Nat Med
  doi: 10.1038/nm0396-342
– volume: 82
  start-page: 1463
  year: 2002
  ident: ref19
  article-title: Gene array identification of Epstein Barr virus-regulated cellular genes in EBV-converted Burkitt lymphoma cell lines
  publication-title: Lab Invest
  doi: 10.1097/01.LAB.0000035025.51772.2B
– volume: 70
  start-page: 1
  year: 2015
  ident: ref24
  article-title: The JCPYV DNA load inversely correlates with the viral microrna expression in blood and cerebrospinal fluid of patients at risk of PML
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2015.06.104
– volume: 18
  start-page: 883
  year: 2012
  ident: ref32
  article-title: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
  publication-title: Nat Med
  doi: 10.1038/nm.2753
– volume: 266
  start-page: 1865
  year: 1994
  ident: ref18
  article-title: Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
  publication-title: Science
  doi: 10.1126/science.7997879
– volume: 58
  start-page: 394
  year: 1999
  ident: ref13
  article-title: Establishing and characterizing a CD30-positive cell line harboring HHV-8 from a primary effusion lymphoma
  publication-title: J Med Virol
  doi: 10.1002/(SICI)1096-9071(199908)58:4<394::AID-JMV12>3.0.CO;2-H
– volume: 81
  start-page: 272
  year: 1990
  ident: ref17
  article-title: Detection of Epstein-Barr virus DNA in Reed-Sternberg cells of Hodgkin's disease using the polymerase chain reaction and in situ hybridization
  publication-title: Jpn J Cancer Res
  doi: 10.1111/j.1349-7006.1990.tb02561.x
– volume: 38
  start-page: S25
  issue: Suppl
  year: 2006
  ident: ref3
  article-title: Viruses and microRNAs
  publication-title: Nat Genet
  doi: 10.1038/ng1793
– volume: 85
  start-page: 9801
  year: 2011
  ident: ref7
  article-title: The members of an Epstein-Barr virus microRNA cluster cooperate to transform B lymphocytes
  publication-title: J Virol
  doi: 10.1128/JVI.05100-11
– volume: 3
  start-page: 1156
  year: 2002
  ident: ref33
  article-title: Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
  publication-title: Nat Immunol
  doi: 10.1038/ni854
– volume: 87
  start-page: 8135
  year: 2013
  ident: ref8
  article-title: Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE
  publication-title: J Virol
  doi: 10.1128/JVI.03159-12
– volume: 276
  start-page: 9910
  year: 2001
  ident: ref20
  article-title: Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M009641200
– volume: 7
  start-page: e1001294
  year: 2011
  ident: ref6
  article-title: A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1001294
– volume: 26
  start-page: 1287
  year: 2012
  ident: ref31
  article-title: Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers
  publication-title: Genes Dev
  doi: 10.1101/gad.192351.112
– volume: 2
  start-page: 269
  year: 2005
  ident: ref5
  article-title: Identification of microRNAs of the herpesvirus family
  publication-title: Nat Methods
  doi: 10.1038/nmeth746
– volume: 11
  start-page: 37
  year: 2016
  ident: ref16
  article-title: Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi's sarcoma-associated herpesvirus
  publication-title: Infect Agent Cancer
  doi: 10.1186/s13027-016-0086-5
– volume: 3
  start-page: 228
  year: 2012
  ident: ref34
  article-title: Role of exosomes/microvesicles in the nervous system and use in emerging therapies
  publication-title: Front Physiol
– volume: 107
  start-page: 20370
  year: 2010
  ident: ref11
  article-title: Human tumor virus utilizes exosomes for intercellular communication
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1014194107
– volume: 4
  start-page: 2980
  year: 2013
  ident: ref12
  article-title: Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
  publication-title: Nat Commun
  doi: 10.1038/ncomms3980
– volume: 9
  start-page: 654
  year: 2007
  ident: ref2
  article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1596
– volume: 9
  start-page: e1003484
  year: 2013
  ident: ref15
  article-title: Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003484
– volume: 9
  start-page: e99163
  year: 2014
  ident: ref9
  article-title: Epstein-Barr virus-encoded small RNAs (EBERs) are present in fractions related to exosomes released by EBV-transformed cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0099163
– volume: 107
  start-page: 6328
  year: 2010
  ident: ref10
  article-title: Functional delivery of viral miRNAs via exosomes
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0914843107
– volume: 315
  start-page: 97
  year: 2007
  ident: ref27
  article-title: A hexanucleotide element directs microRNA nuclear import
  publication-title: Science
  doi: 10.1126/science.1136235
– volume: 102
  start-page: 4336
  year: 2003
  ident: ref22
  article-title: Lipid raft-associated protein sorting in exosomes
  publication-title: Blood
  doi: 10.1182/blood-2003-03-0871
– volume: 33
  start-page: e179
  year: 2005
  ident: ref29
  article-title: Real-time quantification of microRNAs by stem-loop RT-PCR
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gni178
– volume: 455
  start-page: 218
  year: 2014
  ident: ref23
  article-title: Exosome-associated hepatitis C virus in cell cultures and patient plasma
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2014.10.146
– volume: 74
  start-page: 1844
  year: 1989
  ident: ref21
  article-title: Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions
  publication-title: Blood
  doi: 10.1182/blood.V74.5.1844.1844
– volume: 138
  start-page: 1077
  year: 1997
  ident: ref28
  article-title: Transport and localization elements in myelin basic protein mRNA
  publication-title: J Cell Biol
  doi: 10.1083/jcb.138.5.1077
– volume: 85
  start-page: 996
  year: 2011
  ident: ref30
  article-title: Quantitative studies of Epstein-Barr virus-encoded microRNAs provide novel insights into their regulation
  publication-title: J Virol
  doi: 10.1128/JVI.01528-10
– reference: 21752900 - J Virol. 2011 Oct;85(19):9801-10
– reference: 22713869 - Genes Dev. 2012 Jun 15;26(12):1287-99
– reference: 24896633 - PLoS One. 2014 Jun 04;9(6):e99163
– reference: 9281585 - J Cell Biol. 1997 Sep 8;138(5):1077-87
– reference: 23874201 - PLoS Pathog. 2013;9(7):e1003484
– reference: 22635005 - Nat Med. 2012 Jun;18(6):883-91
– reference: 17204650 - Science. 2007 Jan 5;315(5808):97-100
– reference: 21068248 - J Virol. 2011 Jan;85(2):996-1010
– reference: 12426563 - Nat Immunol. 2002 Dec;3(12):1156-62
– reference: 2790208 - Blood. 1989 Oct;74(5):1844-51
– reference: 20691904 - Cell. 2010 Aug 6;142(3):456-67
– reference: 12429807 - Lab Invest. 2002 Nov;82(11):1463-79
– reference: 22754538 - Front Physiol. 2012 Jun 27;3:228
– reference: 12154376 - Nat Rev Immunol. 2002 Aug;2(8):569-79
– reference: 17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9
– reference: 8612236 - Nat Med. 1996 Mar;2(3):342-6
– reference: 15118162 - Science. 2004 Apr 30;304(5671):734-6
– reference: 20950422 - Virol J. 2010 Oct 15;7:271
– reference: 16736021 - Nat Genet. 2006 Jun;38 Suppl:S25-30
– reference: 12881314 - Blood. 2003 Dec 15;102(13):4336-44
– reference: 21059916 - Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20370-5
– reference: 27536332 - Infect Agent Cancer. 2016 Aug 17;11:37
– reference: 16314309 - Nucleic Acids Res. 2005 Nov 27;33(20):e179
– reference: 15782219 - Nat Methods. 2005 Apr;2(4):269-76
– reference: 21379335 - PLoS Pathog. 2011 Feb;7(2):e1001294
– reference: 26305810 - J Clin Virol. 2015 Sep;70:1-6
– reference: 20304794 - Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33
– reference: 25449270 - Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):218-22
– reference: 24356509 - Nat Commun. 2013;4:2980
– reference: 2161814 - Jpn J Cancer Res. 1990 Mar;81(3):272-8
– reference: 11133993 - J Biol Chem. 2001 Mar 30;276(13):9910-6
– reference: 7997879 - Science. 1994 Dec 16;266(5192):1865-9
– reference: 10421407 - J Med Virol. 1999 Aug;58(4):394-401
– reference: 23678170 - J Virol. 2013 Jul;87(14):8135-44
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Snippet Exosomes are small vesicles released from cells, into which microRNAs (miRNA) are specifically sorted and accumulated. Two gamma-herpesviruses, Kaposi...
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SubjectTerms Biology and life sciences
Biotechnology
Blotting, Western
Cell Line, Tumor
Comparative analysis
Deoxyribonucleic acid
DNA
Epstein-Barr virus
Exosomes
Exosomes - genetics
Exosomes - metabolism
Exosomes - ultrastructure
Exosomes - virology
Genomes
Genomics
Herpesviridae
Herpesviridae - genetics
Herpesvirus
High-Throughput Nucleotide Sequencing
Hostages
Humans
Infectious diseases
Intracellular
Kaposi's sarcoma-associated herpesvirus
Localization
Lymphoma
Lymphoma - genetics
Lymphoma - metabolism
Lymphoma - virology
Lymphomas
MicroRNA
MicroRNAs
MicroRNAs - genetics
Microscopy, Electron
miRNA
Pathogens
Pathology
Pediatrics
Polymerase Chain Reaction
Proteins
Research and Analysis Methods
Reverse Transcriptase Polymerase Chain Reaction
Ribonucleic acid
RNA
Sarcoma
Tumor cell lines
Viruses
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Title Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines
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http://dx.doi.org/10.1371/journal.pone.0162574
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