Discovery and Characterization of Phage Display-Derived Human Monoclonal Antibodies against RSV F Glycoprotein

• Published in: PloS one Vol. 11; no. 6; p. e0156798
• Main Authors: Chen, Zhifeng, Zhang, Lan, Tang, Aimin, Callahan, Cheryl, Pristatsky, Pavlo, Swoyer, Ryan, Cejas, Pedro, Nahas, Debbie, Galli, Jennifer, Cosmi, Scott, DiStefano, Daniel, Hoang, Van M., Bett, Andrew, Casimiro, Danilo, Vora, Kalpit A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.06.2016; Public Library of Science (PLoS)
• Subjects: Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Antibodies, Viral - immunology; Antibodies, Viral - therapeutic use; Bacteriophages; Binding; Biology and Life Sciences; Cell Surface Display Techniques; Epitope Mapping; Epitopes - immunology; F protein; Geriatrics; Glycoproteins; Glycoproteins - immunology; Gold; Health aspects; Humans; Immunization; Immunoglobulins; Infants; Infections; Infectious diseases; Laboratories; Medicine and Health Sciences; Molecular biology; Monoclonal antibodies; Neutralizing; Older people; Panning; Phage display; Phages; Physical Sciences; Properties; Proteins; R&D; Research & development; Research and Analysis Methods; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus Vaccines - therapeutic use; Respiratory Syncytial Viruses - drug effects; Respiratory Syncytial Viruses - immunology; Respiratory Syncytial Viruses - pathogenicity; Respiratory tract; Respiratory tract diseases; Vaccines; Virology; Viruses; United States > US

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants, the elderly and in immunosuppressed populations. The vast majority of neutralizing antibodies isolated from human subjects target the RSV fusion (F) glycoprotein, making it an attractive target for...