Immune Response and Mitochondrial Metabolism Are Commonly Deregulated in DMD and Aging Skeletal Muscle

• Published in: PloS one Vol. 6; no. 11; p. e26952
• Main Authors: Baron, Daniel, Magot, Armelle, Ramstein, Gérard, Steenman, Marja, Fayet, Guillemette, Chevalier, Catherine, Jourdon, Philippe, Houlgatte, Rémi, Savagner, Frédérique, Pereon, Yann
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.11.2011; Public Library of Science (PLoS)
• Subjects: Adaptive Immunity - genetics; Adaptive Immunity - physiology; Adolescent; Age; Aging; Aging - genetics; Analysis; Apoptosis; Atrophy; Automation; Biochemistry, Molecular Biology; Bioinformatics; Biology; Child; Cluster Analysis; Datasets; Degeneration; Deoxyribonucleic acid; Deregulation; DNA; DNA binding proteins; DNA microarrays; Duchenne's muscular dystrophy; Dystrophy; ERRalpha Estrogen-Related Receptor; Ets-1 protein; Fibrosis; Gene expression; Genes; Genetics; Genomes; Genomics; Human genetics; Human health and pathology; Humans; Immune response; Immune system; In Vitro Techniques; Interferon regulatory factor 1; Interferon Regulatory Factor-1 - genetics; Life Sciences; Male; Medicine; Metabolism; Mitochondria; Mitochondria - metabolism; Morphology; Muscle, Skeletal - immunology; Muscle, Skeletal - metabolism; Muscular dystrophy; Muscular Dystrophy, Duchenne - genetics; Muscular Dystrophy, Duchenne - immunology; Muscular Dystrophy, Duchenne - metabolism; Musculoskeletal system; Neurofibromin 1 - genetics; Oligonucleotide Array Sequence Analysis; Oncorhynchus mykiss; Physiological aspects; Prostate cancer; Protein synthesis; Proteins; Proto-Oncogene Protein c-ets-1 - genetics; Receptors, Estrogen - genetics; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Sarcopenia; Semantics; Signatures; Skeletal muscle; Thorax; Tissues and Organs; Transcription (Genetics); Transcription factors; France

Duchenne Muscular Dystrophy (DMD) is a complex process involving multiple pathways downstream of the primary genetic insult leading to fatal muscle degeneration. Aging muscle is a multifactorial neuromuscular process characterized by impaired muscle regeneration leading to progressive atrophy. We hy...