Impact of Diabetes, Drug-Induced Liver Injury, and Sepsis on Outcomes in Metabolic Dysfunction Associated Fatty Liver Disease–Related Acute-on-Chronic Liver Failure

The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its complication, MAFLD-related acute-on-chronic liver failure (MAFLD-ACLF), is rising. Yet, factors determining patient outcomes in MAFLD-ACLF remain understudied.INTRODUCTIONThe prevalence of metabolic dysfunction-a...

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Published inThe American journal of gastroenterology
Main Authors Kumar, Ashish, Arora, Anil, Choudhury, Ashok, Arora, Vinod, Rela, Mohamed, Jothimani, Dinesh Kumar, Mahtab, Mamun A., Devarbhavi, Harshad, Eapen, Chundamanni E., Goel, Ashish, Yaghi, Cesar, Ning, Qin, Chen, Tao, Jia, Jidong, Zhongping, Duan, Hamid, Saeed S., Butt, Amna S., Jafri, Wasim, Shukla, Akash, Tan, Seok S., Kim, Dong J., Saraya, Anoop, Hu, Jinhua, Sood, Ajit, Goyal, Omesh, Midha, Vandana, Pati, Girish K., Singh, Ayaskant, Lee, Guan H., Treeprasertsuk, Sombat, Thanapirom, Kessarin, Mandot, Ameet, Maghade, Ravikiran, Lesmana, Rinaldi C., Ghazinyan, Hasmik, Mohan Prasad, Virukalpatti G., Dokmeci, Abdul K., Sollano, Jose D., Abbas, Zaigham, Shrestha, Ananta, Lau, George K., Payawal, Diana A., Shiha, Gamal E., Duseja, Ajay, Taneja, Sunil, Verma, Nipun, Rao, Padaki N., Kulkarni, Anand V., Karim, Fazal, Saraswat, Vivek A., Alam, Shahinul, Chowdhury, Debashis, Kedarisetty, Chandan K., Saigal, Sanjiv, Sharma, Praveen, Yattoo, Ghulam N., Koshy, Abraham, Patwa, Ajay K., Elbasiony, Mohamed, Rathi, Pravin M., Maharshi, Sudhir, Dayal, Vishwa M., Jha, Ashish K., Kalista, Kemal F., Gani, Rino A., Yuen, Man F., Singh, Virendra, Sargsyan, Violeta A., Huang, Chien H., Mukewar, Saurabh S., Xin, Shaojie, Rajaram, Ruveena B., Panackel, Charles, Dadhich, Sunil, Sachdeva, Sanjeev, Kumar, Ajay, Behera, Sanatan, Kamani, Lubna, Saithanyamurthi, Hemamala V., Prasad, Babita, Sarin, Shiv K.
Format Journal Article
LanguageEnglish
Published 17.07.2024
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Abstract The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its complication, MAFLD-related acute-on-chronic liver failure (MAFLD-ACLF), is rising. Yet, factors determining patient outcomes in MAFLD-ACLF remain understudied.INTRODUCTIONThe prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its complication, MAFLD-related acute-on-chronic liver failure (MAFLD-ACLF), is rising. Yet, factors determining patient outcomes in MAFLD-ACLF remain understudied.Patients with MAFLD-ACLF were recruited from the Asian Pacific Association for the Study of the Liver-ACLF Research Consortium (AARC registry). The diagnosis of MAFLD-ACLF was made when the treating unit had identified the etiology of chronic liver disease as MAFLD (or previous nomenclature such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, or non-alcoholic steatohepatitis-cirrhosis). Patients with coexisting other etiologies of chronic liver disease (such as alcohol, hepatitis B virus, hepatitis C virus, etc.) were excluded. Data were randomly split into derivation (n = 258) and validation (n = 111) cohorts at a 70:30 ratio. The primary outcome was 90-day mortality. Only the baseline clinical, laboratory features and severity scores were considered.METHODSPatients with MAFLD-ACLF were recruited from the Asian Pacific Association for the Study of the Liver-ACLF Research Consortium (AARC registry). The diagnosis of MAFLD-ACLF was made when the treating unit had identified the etiology of chronic liver disease as MAFLD (or previous nomenclature such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, or non-alcoholic steatohepatitis-cirrhosis). Patients with coexisting other etiologies of chronic liver disease (such as alcohol, hepatitis B virus, hepatitis C virus, etc.) were excluded. Data were randomly split into derivation (n = 258) and validation (n = 111) cohorts at a 70:30 ratio. The primary outcome was 90-day mortality. Only the baseline clinical, laboratory features and severity scores were considered.The derivation group had 258 patients; 60% were male, with a mean age of 53. Diabetes was noted in 27% and hypertension in 29%. The dominant precipitants included viral hepatitis (hepatitis A virus and hepatitis E virus, 32%), drug-induced injury (drug-induced liver injury, 29%), and sepsis (23%). Model for End-Stage Liver Disease-Sodium (MELD-Na) and AARC scores on admission averaged 32 ± 6 and 10.4 ± 1.9. At 90 days, 51% survived. Nonviral precipitant, diabetes, bilirubin, international normalized ratio, and encephalopathy were independent factors influencing mortality. Adding diabetes and precipitant to MELD-Na and AARC scores, the novel MAFLD-MELD-Na score (+12 for diabetes, +12 for nonviral precipitant), and MAFLD-AARC score (+5 for each) were formed. These outperformed the standard scores in both cohorts.RESULTSThe derivation group had 258 patients; 60% were male, with a mean age of 53. Diabetes was noted in 27% and hypertension in 29%. The dominant precipitants included viral hepatitis (hepatitis A virus and hepatitis E virus, 32%), drug-induced injury (drug-induced liver injury, 29%), and sepsis (23%). Model for End-Stage Liver Disease-Sodium (MELD-Na) and AARC scores on admission averaged 32 ± 6 and 10.4 ± 1.9. At 90 days, 51% survived. Nonviral precipitant, diabetes, bilirubin, international normalized ratio, and encephalopathy were independent factors influencing mortality. Adding diabetes and precipitant to MELD-Na and AARC scores, the novel MAFLD-MELD-Na score (+12 for diabetes, +12 for nonviral precipitant), and MAFLD-AARC score (+5 for each) were formed. These outperformed the standard scores in both cohorts.Almost half of patients with MAFLD-ACLF die within 90 days. Diabetes and nonviral precipitants such as drug-induced liver injury and sepsis lead to adverse outcomes. The new MAFLD-MELD-Na and MAFLD-AARC scores provide reliable 90-day mortality predictions for patients with MAFLD-ACLF.DISCUSSIONAlmost half of patients with MAFLD-ACLF die within 90 days. Diabetes and nonviral precipitants such as drug-induced liver injury and sepsis lead to adverse outcomes. The new MAFLD-MELD-Na and MAFLD-AARC scores provide reliable 90-day mortality predictions for patients with MAFLD-ACLF.
AbstractList The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its complication, MAFLD-related acute-on-chronic liver failure (MAFLD-ACLF), is rising. Yet, factors determining patient outcomes in MAFLD-ACLF remain understudied.INTRODUCTIONThe prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its complication, MAFLD-related acute-on-chronic liver failure (MAFLD-ACLF), is rising. Yet, factors determining patient outcomes in MAFLD-ACLF remain understudied.Patients with MAFLD-ACLF were recruited from the Asian Pacific Association for the Study of the Liver-ACLF Research Consortium (AARC registry). The diagnosis of MAFLD-ACLF was made when the treating unit had identified the etiology of chronic liver disease as MAFLD (or previous nomenclature such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, or non-alcoholic steatohepatitis-cirrhosis). Patients with coexisting other etiologies of chronic liver disease (such as alcohol, hepatitis B virus, hepatitis C virus, etc.) were excluded. Data were randomly split into derivation (n = 258) and validation (n = 111) cohorts at a 70:30 ratio. The primary outcome was 90-day mortality. Only the baseline clinical, laboratory features and severity scores were considered.METHODSPatients with MAFLD-ACLF were recruited from the Asian Pacific Association for the Study of the Liver-ACLF Research Consortium (AARC registry). The diagnosis of MAFLD-ACLF was made when the treating unit had identified the etiology of chronic liver disease as MAFLD (or previous nomenclature such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, or non-alcoholic steatohepatitis-cirrhosis). Patients with coexisting other etiologies of chronic liver disease (such as alcohol, hepatitis B virus, hepatitis C virus, etc.) were excluded. Data were randomly split into derivation (n = 258) and validation (n = 111) cohorts at a 70:30 ratio. The primary outcome was 90-day mortality. Only the baseline clinical, laboratory features and severity scores were considered.The derivation group had 258 patients; 60% were male, with a mean age of 53. Diabetes was noted in 27% and hypertension in 29%. The dominant precipitants included viral hepatitis (hepatitis A virus and hepatitis E virus, 32%), drug-induced injury (drug-induced liver injury, 29%), and sepsis (23%). Model for End-Stage Liver Disease-Sodium (MELD-Na) and AARC scores on admission averaged 32 ± 6 and 10.4 ± 1.9. At 90 days, 51% survived. Nonviral precipitant, diabetes, bilirubin, international normalized ratio, and encephalopathy were independent factors influencing mortality. Adding diabetes and precipitant to MELD-Na and AARC scores, the novel MAFLD-MELD-Na score (+12 for diabetes, +12 for nonviral precipitant), and MAFLD-AARC score (+5 for each) were formed. These outperformed the standard scores in both cohorts.RESULTSThe derivation group had 258 patients; 60% were male, with a mean age of 53. Diabetes was noted in 27% and hypertension in 29%. The dominant precipitants included viral hepatitis (hepatitis A virus and hepatitis E virus, 32%), drug-induced injury (drug-induced liver injury, 29%), and sepsis (23%). Model for End-Stage Liver Disease-Sodium (MELD-Na) and AARC scores on admission averaged 32 ± 6 and 10.4 ± 1.9. At 90 days, 51% survived. Nonviral precipitant, diabetes, bilirubin, international normalized ratio, and encephalopathy were independent factors influencing mortality. Adding diabetes and precipitant to MELD-Na and AARC scores, the novel MAFLD-MELD-Na score (+12 for diabetes, +12 for nonviral precipitant), and MAFLD-AARC score (+5 for each) were formed. These outperformed the standard scores in both cohorts.Almost half of patients with MAFLD-ACLF die within 90 days. Diabetes and nonviral precipitants such as drug-induced liver injury and sepsis lead to adverse outcomes. The new MAFLD-MELD-Na and MAFLD-AARC scores provide reliable 90-day mortality predictions for patients with MAFLD-ACLF.DISCUSSIONAlmost half of patients with MAFLD-ACLF die within 90 days. Diabetes and nonviral precipitants such as drug-induced liver injury and sepsis lead to adverse outcomes. The new MAFLD-MELD-Na and MAFLD-AARC scores provide reliable 90-day mortality predictions for patients with MAFLD-ACLF.
Author Jha, Ashish K.
Yaghi, Cesar
Sargsyan, Violeta A.
Maghade, Ravikiran
Kim, Dong J.
Chen, Tao
Kedarisetty, Chandan K.
Lesmana, Rinaldi C.
Sollano, Jose D.
Sarin, Shiv K.
Jothimani, Dinesh Kumar
Ning, Qin
Ghazinyan, Hasmik
Xin, Shaojie
Verma, Nipun
Karim, Fazal
Mukewar, Saurabh S.
Saithanyamurthi, Hemamala V.
Lau, George K.
Payawal, Diana A.
Behera, Sanatan
Goyal, Omesh
Devarbhavi, Harshad
Shrestha, Ananta
Zhongping, Duan
Eapen, Chundamanni E.
Jafri, Wasim
Alam, Shahinul
Chowdhury, Debashis
Singh, Virendra
Mandot, Ameet
Yuen, Man F.
Goel, Ashish
Arora, Anil
Pati, Girish K.
Sachdeva, Sanjeev
Sood, Ajit
Arora, Vinod
Saraya, Anoop
Shiha, Gamal E.
Rathi, Pravin M.
Patwa, Ajay K.
Panackel, Charles
Saigal, Sanjiv
Butt, Amna S.
Duseja, Ajay
Dadhich, Sunil
Tan, Seok S.
Sharma, Praveen
Kumar, Ajay
Elbasiony, Mohamed
Rajaram, Ruveena B.
Kamani, Lubna
Thanapirom, Kessarin
Rao, Padaki N.
Saraswat, Vivek A.
Yattoo, Ghulam N.
Jia, Jidong
Kulkarni, Anand V.
Kumar, Ashish
Prasad, Babita
Huang, Chien H.
Rela, Mohamed
Midha, Vandana
Treeprasertsuk, Sombat
Choudhury, Asho
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Cites_doi 10.14309/ajg.0000000000001595
10.1038/nrgastro.2015.219
10.1007/s12072-008-9106-x
10.1002/cld.1146
10.1097/HEP.0000000000000004
10.1111/jgh.13084
10.1038/s41575-021-00523-4
10.1007/s12072-014-9580-2
10.1038/s41575-021-00448-y
10.14309/ajg.0000000000000433
10.1016/j.jhep.2018.10.033
10.21037/tgh.2019.09.11
10.1056/NEJMra1914900
10.1016/S0140-6736(20)32511-3
10.1016/j.jceh.2013.08.013
10.1007/s12072-019-09946-3
10.1016/j.jhep.2023.04.036
10.1007/s12072-020-10094-2
10.1111/liv.15328
10.1016/j.jceh.2019.04.050
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References Wong (R6-20240919) 2023; 79
Eslam (R1-20240919) 2020; 14
Kim (R19-20240919) 2016; 31
Powell (R2-20240919) 2021; 397
Sarin (R10-20240919) 2014; 8
Younossi (R4-20240919) 2023; 77
Sarin (R11-20240919) 2016; 13
Lazarus (R3-20240919) 2022; 19
Kumar (R15-20240919) 2013; 3
Sarin (R9-20240919) 2019; 13
Aggarwal (R14-20240919) 2021; 18
Younossi (R5-20240919) 2019; 70
Jindal (R13-20240919) 2022; 42
Sarin (R8-20240919) 2009; 3
Gawande (R16-20240919) 2019; 9
Bajaj (R20-20240919) 2022; 117
Younossi (R18-20240919) 2019; 114
Arroyo (R12-20240919) 2020; 382
Singal (R7-20240919) 2019; 4
Targher (R17-20240919) 2021; 18
References_xml – volume: 117
  start-page: 225
  issue: 2
  year: 2022
  ident: R20-20240919
  article-title: Acute-on-Chronic liver failure clinical guidelines
  publication-title: Am J Gastroenterol
  doi: 10.14309/ajg.0000000000001595
  contributor:
    fullname: Bajaj
– volume: 13
  start-page: 131
  issue: 3
  year: 2016
  ident: R11-20240919
  article-title: Acute-on-chronic liver failure: Terminology, mechanisms and management
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/nrgastro.2015.219
  contributor:
    fullname: Sarin
– volume: 3
  start-page: 269
  issue: 1
  year: 2009
  ident: R8-20240919
  article-title: Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)
  publication-title: Hepatol Int
  doi: 10.1007/s12072-008-9106-x
  contributor:
    fullname: Sarin
– volume: 18
  start-page: 168
  issue: 3
  year: 2021
  ident: R14-20240919
  article-title: Hepatitis E: Current status in India
  publication-title: Clin Liver Dis
  doi: 10.1002/cld.1146
  contributor:
    fullname: Aggarwal
– volume: 77
  start-page: 1335
  issue: 4
  year: 2023
  ident: R4-20240919
  article-title: The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review
  publication-title: Hepatology
  doi: 10.1097/HEP.0000000000000004
  contributor:
    fullname: Younossi
– volume: 31
  start-page: 427
  issue: 2
  year: 2016
  ident: R19-20240919
  article-title: Characterization of acute-on-chronic liver failure and prediction of mortality in Asian patients with active alcoholism
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/jgh.13084
  contributor:
    fullname: Kim
– volume: 19
  start-page: 60
  issue: 1
  year: 2022
  ident: R3-20240919
  article-title: Advancing the global public health agenda for NAFLD: A consensus statement
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-021-00523-4
  contributor:
    fullname: Lazarus
– volume: 8
  start-page: 453
  issue: 4
  year: 2014
  ident: R10-20240919
  article-title: Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014
  publication-title: Hepatol Int
  doi: 10.1007/s12072-014-9580-2
  contributor:
    fullname: Sarin
– volume: 18
  start-page: 599
  issue: 9
  year: 2021
  ident: R17-20240919
  article-title: The complex link between NAFLD and type 2 diabetes mellitus–mechanisms and treatments
  publication-title: Nat Rev Gastroenterol Hepatol
  doi: 10.1038/s41575-021-00448-y
  contributor:
    fullname: Targher
– volume: 114
  start-page: 1714
  issue: 11
  year: 2019
  ident: R18-20240919
  article-title: The impact of obesity and type 2 diabetes on chronic liver disease
  publication-title: Am J Gastroenterol
  doi: 10.14309/ajg.0000000000000433
  contributor:
    fullname: Younossi
– volume: 70
  start-page: 531
  issue: 3
  year: 2019
  ident: R5-20240919
  article-title: Non-alcoholic fatty liver disease: A global public health perspective
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2018.10.033
  contributor:
    fullname: Younossi
– volume: 4
  start-page: 74
  year: 2019
  ident: R7-20240919
  article-title: Acute on chronic liver failure in non-alcoholic fatty liver and alcohol associated liver disease
  publication-title: Transl Gastroenterol Hepatol
  doi: 10.21037/tgh.2019.09.11
  contributor:
    fullname: Singal
– volume: 382
  start-page: 2137
  issue: 22
  year: 2020
  ident: R12-20240919
  article-title: Acute-on-chronic liver failure
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1914900
  contributor:
    fullname: Arroyo
– volume: 397
  start-page: 2212
  issue: 10290
  year: 2021
  ident: R2-20240919
  article-title: Non-alcoholic fatty liver disease
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)32511-3
  contributor:
    fullname: Powell
– volume: 3
  start-page: 225
  year: 2013
  ident: R15-20240919
  article-title: Hepatitis E and acute-on-chronic liver failure
  publication-title: J Clin Exp Hepatol
  doi: 10.1016/j.jceh.2013.08.013
  contributor:
    fullname: Kumar
– volume: 13
  start-page: 353
  issue: 4
  year: 2019
  ident: R9-20240919
  article-title: Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL): An update
  publication-title: Hepatol Int
  doi: 10.1007/s12072-019-09946-3
  contributor:
    fullname: Sarin
– volume: 79
  start-page: 842
  issue: 3
  year: 2023
  ident: R6-20240919
  article-title: Changing epidemiology, global trends and implications for outcomes of NAFLD
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2023.04.036
  contributor:
    fullname: Wong
– volume: 14
  start-page: 889
  issue: 6
  year: 2020
  ident: R1-20240919
  article-title: The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease
  publication-title: Hepatol Int
  doi: 10.1007/s12072-020-10094-2
  contributor:
    fullname: Eslam
– volume: 42
  start-page: 2093
  issue: 9
  year: 2022
  ident: R13-20240919
  article-title: Epidemiology of liver failure in Asia-Pacific region
  publication-title: Liver Int
  doi: 10.1111/liv.15328
  contributor:
    fullname: Jindal
– volume: 9
  start-page: 699
  issue: 6
  year: 2019
  ident: R16-20240919
  article-title: Acute-on-Chronic liver failure: Etiology of chronic and acute precipitating factors and their effect on mortality
  publication-title: J Clin Exp Hepatol
  doi: 10.1016/j.jceh.2019.04.050
  contributor:
    fullname: Gawande
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Title Impact of Diabetes, Drug-Induced Liver Injury, and Sepsis on Outcomes in Metabolic Dysfunction Associated Fatty Liver Disease–Related Acute-on-Chronic Liver Failure
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