Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

• Published in: PloS one Vol. 5; no. 11; p. e13788
• Main Authors: Sanz-Arigita, Ernesto J., Schoonheim, Menno M., Damoiseaux, Jessica S., Rombouts, Serge A. R. B., Maris, Erik, Barkhof, Frederik, Scheltens, Philip, Stam, Cornelis J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2010; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Advertising executives; Age; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Attention deficit hyperactivity disorder; Brain; Brain - pathology; Brain - physiopathology; Brain mapping; Brain Mapping - methods; Clusters; Cognition & reasoning; Cognitive ability; Computational Biology/Computational Neuroscience; Cortex; Dementia; Departments; Female; Functional magnetic resonance imaging; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical research; Memory; Middle Aged; Models, Neurological; Nerve Net - pathology; Nerve Net - physiopathology; Networks; Neural networks; Neurodegenerative diseases; Neuroimaging; Neurological Disorders/Alzheimer Disease; Neurology; NMR; Nuclear magnetic resonance; Patients; Radiology and Medical Imaging/Magnetic Resonance Imaging; Regional analysis; Rest; Structure-function relationships; Synchronism; Synchronization; Time synchronization; Young Adult; Netherlands

Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however, show more global long distance connectivity changes, both in functional and structural imaging data. The fo...