Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells

• Published in: PloS one Vol. 5; no. 6; p. e10966
• Main Authors: Zeng, Min, Kikuchi, Hirotoshi, Pino, Maria S., Chung, Daniel C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.06.2010; Public Library of Science (PLoS)
• Subjects: Activation; Adaptation; Adaptations; AKT protein; Angiogenesis; Apoptosis; Apoptosis - genetics; Cancer; Cancer genetics; Cell Biology; Cell Biology/Cell Signaling; Cell Biology/Cellular Death and Stress Responses; Cell Hypoxia; Cell survival; Colon; Colon cancer; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colorectal cancer; Development and progression; Epidermal growth factor receptors; Genes, ras; Genetic aspects; Growth factor receptors; GTP; Guanosine triphosphate; Humans; Hypoxia; K-Ras protein; Kinases; Mutation; Neovascularization, Pathologic - genetics; Oncogenes; Oxygen; Phosphorylation; Receptors; RNA, Small Interfering; Signaling; siRNA; Src protein; Tumor cell lines; Tumors; Up-Regulation; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - biosynthesis; United States > US; Massachusetts

The KRAS proto-oncogene plays a key role in the development of many human tumors and is commonly activated by somatic mutation or signaling through specific growth factor receptors. However, the interaction between the micro-environment and K-ras activity has not been defined. Hypoxia invariably dev...