Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells - Zeng, Min; Kikuchi, Hirotoshi; Pino, Maria S.; Chung, Daniel C. (PloS one, 2010)
Keywords: Activation; Adaptation; Adaptations; AKT protein; Angiogenesis; Apoptosis; Apoptosis - genetics; Cancer; Cancer genetics; Cell Biology; Cell Biology/Cell Signaling; Cell Biology/Cellular Death and Stress Responses; Cell Hypoxia; Cell survival; Colon; Colon cancer; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colorectal cancer; Development and progression; Epidermal growth factor receptors; Genes, ras; Genetic aspects; Growth factor receptors; GTP; Guanosine triphosphate; Humans; Hypoxia; K-Ras protein; Kinases; Mutation; Neovascularization, Pathologic - genetics; Oncogenes; Oxygen; Phosphorylation; Receptors; RNA, Small Interfering; Signaling; siRNA; Src protein; Tumor cell lines; Tumors; Up-Regulation; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - biosynthesis; United States--US; Massachusetts