Defective interfering influenza virus confers only short-lived protection against influenza virus disease: Evidence for a role for adaptive immunity in DI virus-mediated protection in vivo

• Published in: Vaccine Vol. 29; no. 38; pp. 6584 - 6591
• Main Authors: Scott, Paul D., Meng, Bo, Marriott, Anthony C., Easton, Andrew J., Dimmock, Nigel J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 02.09.2011; Elsevier; Elsevier Limited; Elsevier Science
• Subjects: acute course; Adaptive Immunity; Allergy and Immunology; Animals; Applied microbiology; Atoms & subatomic particles; B-Lymphocytes - immunology; Biological and medical sciences; Cloning; Competition; Defective interfering; Defective Viruses - immunology; Disease; Fundamental and applied biological sciences. Psychology; genome; Genomes; Immune system; Immunity; Infections; Influenza; Influenza A virus; Influenza A virus - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Killer Cells, Natural - immunology; Lung - virology; lungs; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, SCID; Microbiology; Miscellaneous; nucleotide sequences; Orthomyxoviridae; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - prevention & control; Orthomyxoviridae Infections - virology; Protection; RNA; SCID; severe combined immunodeficiency; Studies; T-lymphocytes; T-Lymphocytes - immunology; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral Load; Virology; Viruses; Defective interfering; Immunity; Protection; SCID; Influenza; Orthomyxoviridae; Influenzavirus; Infection; Virus; Influenzavirus A; Influenza A virus; Viral disease; Combined immune deficiency

We have shown earlier that a single dose of cloned defective interfering (DI) influenza A virus strongly protects mice from disease following a lethal challenge with different subtypes of influenza A virus. These animals suffered no clinical disease but experienced a subclinical infection which rend...