The Temporal Version of the Pediatric Sepsis Biomarker Risk Model

• Published in: PLoS ONE Vol. 9; no. 3; p. e92121
• Main Authors: Wong, Hector R., Weiss, Scott L., Giuliano, John S., Wainwright, Mark S., Cvijanovich, Natalie Z., Thomas, Neal J., Allen, Geoffrey L., Anas, Nick, Bigham, Michael T., Hall, Mark, Freishtat, Robert J., Sen, Anita, Meyer, Keith, Checchia, Paul A., Shanley, Thomas P., Nowak, Jeffrey, Quasney, Michael, Chopra, Arun, Fitzgerald, Julie C., Gedeit, Rainer, Banschbach, Sharon, Beckman, Eileen, Harmon, Kelli, Lahni, Patrick, Lindsell, Christopher J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 13.03.2014; Public Library of Science
• Subjects: Biology; Biomarkers; Biomarkers - blood; Child; Child health; Child, Preschool; Children; Critical care; Decision trees; Derivation; Female; Gene expression; Genomes; Guardians; Health aspects; Heat-Shock Response; Humans; Infant; Intensive care; Male; Mathematical models; Measurement methods; Medical schools; Medicine; Models, Theoretical; Mortality; Pediatrics; Physiological aspects; Prognosis; Q; R; Regression analysis; Research Article; Review boards; Risk Assessment; Risk factors; Science; Sensitivity; Sepsis; Septic shock; Shock, Septic; Shock, Septic - blood; Shock, Septic - mortality; Shock, Septic - pathology; Statistical analysis

PERSEVERE is a risk model for estimating mortality probability in pediatric septic shock, using five biomarkers measured within 24 hours of clinical presentation. Here, we derive and test a temporal version of PERSEVERE (tPERSEVERE) that considers biomarker values at the first and third day followin...