Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation

• Published in: PloS one Vol. 4; no. 5; p. e5658
• Main Authors: Li, Olive T. W., Chan, Michael C. W., Leung, Cynthia S. W., Chan, Renee W. Y., Guan, Yi, Nicholls, John M., Poon, Leo L. M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.05.2009; Public Library of Science (PLoS)
• Subjects: Adaptation, Biological; Addition polymerization; Amino acids; Animals; Avian flu; Avian influenza; Avian influenza viruses; Binding sites; Birds; Cell Line; Cells; Chemokines; Chickens; Cytokines; Cytokines - metabolism; Dogs; Factorial analysis; Genes; Genes, Viral; Humans; Incubation; Inducers; Infections; Infectious diseases; Inflammation; Inflammation Mediators - metabolism; Influenza; Influenza A virus - enzymology; Influenza A virus - genetics; Influenza in Birds - enzymology; Laboratories; Luciferases - metabolism; Macrophages; Mammals; Mammals - virology; Mutation; Mutation - genetics; Pandemics; Penicillin; Pneumocytes; Polymerase; Protein Subunits - metabolism; Proteins; Ribonucleoproteins; RNA Replicase - metabolism; Selection, Genetic; Serial Passage; Studies; Viral infections; Viral Proteins - metabolism; Virology; Virology/Effects of Virus Infection on Host Gene Expression; Virology/Viral and Gene Regulation; Virology/Virulence Factors and Mechanisms; Viruses

Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play role...