Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model

• Published in: PLOS ONE Vol. 15; no. 7; p. e0236101
• Main Authors: Yang, Cheng-Yu, Tsao, Chang-Huei, Hsieh, Cheng-Chih, Lin, Chih-Kung, Lin, Chun-Shu, Li, Yu-Hsuan, Chang, Wei-Chin, Cheng, Jen-Chen, Lin, Gu-Jiun, Sytwu, Huey-Kang, Wang, Yin-Lai, Chen, Yuan-Wu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 17.07.2020; Public Library of Science
• Subjects: Adjuvants; Animal tissues; Animals; Anticancer properties; Antineoplastic Agents, Phytogenic; Antineoplastic Agents, Phytogenic - pharmacology; Antitumor activity; Apoptosis; Biology and Life Sciences; Biomarkers, Tumor; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cancer research; Cancer therapies; Carcinoma, Squamous Cell; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Care and treatment; Cell cycle; Cell growth; Cell Proliferation; Cervix; Chemotherapy; Composition; Dentistry; Development and progression; Female; Gallbladder diseases; Gene expression; Gene Expression Regulation, Neoplastic; Health aspects; Histone Demethylases; Histone Demethylases - genetics; Histone Demethylases - metabolism; Hospitals; Humans; Hydroxylases; Immunology; Kinases; Maxillofacial surgery; Medical prognosis; Medicine; Medicine and Health Sciences; Metabolism; Metastases; Metastasis; Mice; Mice, Inbred NOD; Mice, SCID; Milk thistle; Mouth cancer; Mouth Neoplasms; Mouth Neoplasms - drug therapy; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Oral cancer; Oral squamous cell carcinoma; Plant extracts; Prognosis; Prostate; Proteins; Q; R; Reagents; Repressor Proteins; Repressor Proteins - genetics; Repressor Proteins - metabolism; Research and Analysis Methods; Research Article; Science; Silibinin; Silybin; Silybin - pharmacology; Squamous cell carcinoma; Studies; Survival; Survival Rate; Therapeutic applications; Trans-Activators; Trans-Activators - genetics; Trans-Activators - metabolism; Tumor cell lines; Tumor Cells, Cultured; Tumorigenesis; Tumors; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation; Taiwan; United States > US

Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a commonly used anti-hepatotoxic drug and exhibits anticancer effect in various cancers. However, the antitumor mechanism between silibinin and JMJD...