Palmitoylation regulates epidermal homeostasis and hair follicle differentiation

• Published in: PLoS genetics Vol. 5; no. 11; p. e1000748
• Main Authors: Mill, Pleasantine, Lee, Angela W S, Fukata, Yuko, Tsutsumi, Ryouhei, Fukata, Masaki, Keighren, Margaret, Porter, Rebecca M, McKie, Lisa, Smyth, Ian, Jackson, Ian J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2009; Public Library of Science (PLoS)
• Subjects: Acyltransferases - genetics; Animals; BASIC BIOLOGICAL SCIENCES; Cell Differentiation; Councils; Dermatology; Developmental Biology/Molecular Development; Developmental Biology/Organogenesis; Developmental Biology/Stem Cells; Embryonic development; Epidermal Cells; Fatty acids; Frameshift Mutation; Genetics & Heredity; Genetics and Genomics/Functional Genomics; Genetics and Genomics/Gene Function; Hair Follicle - cytology; Homeostasis; Kinases; Lipids; Lipoylation - physiology; Mice; Palmitoylation; Post-translational modification; Propagation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins c-fyn - metabolism; Rodents

Palmitoylation is a key post-translational modification mediated by a family of DHHC-containing palmitoyl acyl-transferases (PATs). Unlike other lipid modifications, palmitoylation is reversible and thus often regulates dynamic protein interactions. We find that the mouse hair loss mutant, depilated...