Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians

• Published in: PloS one Vol. 5; no. 5; p. e10667
• Main Authors: Biagi, E, Nylund, L, Candela, M, Ostan, R, Bucci, L, Pini, E, Nikkïla, J, Monti, D, Satokari, R.M, Franceschi, C, Brigidi, P, Vos, W.M. de
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.05.2010; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Aged; Aged, 80 and over; Aging; Aging - pathology; Anaerobes; Anti-inflammatory agents; Archaea; Atherosclerosis; Bacteria; Bacteroidetes; butyrate-producing bacteria; Centenarians; Cluster Analysis; Cytokines - blood; Development and progression; Diabetes; Digestive system; Digestive tract; Disease susceptibility; Ecosystems; Environmental changes; Epidemiology; eubacterium-limosum; fecal microbiota; Feces; Feces - microbiology; Female; Functional foods & nutraceuticals; Gastrointestinal system; Gastrointestinal tract; Gastrointestinal Tract - microbiology; Gastrointestinal Tract - pathology; Geriatrics; Homeostasis; human colon; human feces; human longevity; Humans; Hybridization; Immune system; Immunology; Immunophenotyping; Inflammation; Inflammation - microbiology; Inflammation - pathology; Insulin resistance; Intestinal microflora; Intestine; Lactobacillus acidophilus; Life span; Lymphocyte Subsets - metabolism; Male; Metagenome - genetics; Microbiology; Microbiology/Environmental Microbiology; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Multivariate analysis; Older people; Oldest old people; Pathology; Peripheral blood; Pharmaceutical sciences; Phylogeny; Physiological aspects; Physiology; Polymerase Chain Reaction; real-time pcr; ribosomal-rna gene; RNA; rRNA 16S; t-cells; Veterinary medicine; Young Adult; Young adults; Italy; Finland

Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections. By using the Human Intestinal Tract C...