Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts

• Published in: Indian journal of ophthalmology Vol. 71; no. 5; pp. 2143 - 2151
• Main Authors: Shanbagh, Shaika, Matalia, Jyoti, Kannan, Ramaraj, Shetty, Rohit, Panmand, Pratibha, Muthu, Sumitha O, Chaurasia, Shyam S, Deshpande, Vrushali, Bhattacharya, Shomi S, Gopalakrishnan, Abilash V, Ghosh, Arkasubhra
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.05.2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Analysis; Cataract; Cataract - genetics; Cataract - metabolism; Cataracts; Child; Children; Complications and side effects; Cross-Sectional Studies; Cytomegalovirus; Development and progression; Diagnosis; Eye lens; fibrosis; Gene expression; Genetic aspects; Hsp70 protein; Humans; lens; Lens, Crystalline; Original; Original Article; Pediatric research; Pediatrics; Phenotypes; Postpartum period; Ribonucleoproteins - genetics; Ribonucleoproteins - metabolism; Risk factors; Rubella; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptome; Transforming Growth Factor beta - genetics; Vimentin; Vimentin - genetics; Vimentin - metabolism; Vision disorders in children; India; Cataract; fibrosis; lens; transcription factors; gene expression

Purpose: Pediatric cataract is a major cause of preventable childhood blindness worldwide. Although genetic mutations or infections have been described in patients, the mechanistic basis of human cataract development remains poorly understood. Therefore, gene expression of structural, developmental,...