FLS2-BAK1 extracellular domain interaction sites required for defense signaling activation

• Published in: PloS one Vol. 9; no. 10; p. e111185
• Main Authors: Koller, Teresa, Bent, Andrew F
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.10.2014; Public Library of Science (PLoS)
• Subjects: Amino Acid Substitution; Amino acids; Arabidopsis; Arabidopsis - chemistry; Arabidopsis - enzymology; Arabidopsis - genetics; Arabidopsis Proteins - chemistry; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; BASIC BIOLOGICAL SCIENCES; Biocompatibility; Biology and Life Sciences; Biomedical materials; C-Terminus; co-immunoprecipitation; Conservation; Crystal defects; Crystal structure; Crystallography, X-Ray; Damage patterns; Flagellin; Flowers & plants; Immunoprecipitation; In vivo methods and tests; Kinases; leaves; Leucine; Ligands; Moisture content; Mutagenesis; Mutation; Mutation, Missense; nicotiana; Nicotiana - chemistry; Nicotiana - enzymology; Nicotiana - genetics; Plant cells; Plant pathology; protein interactions; Protein Kinases - chemistry; Protein Kinases - genetics; Protein Kinases - metabolism; Protein Serine-Threonine Kinases - chemistry; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Protein Structure, Quaternary; Protein Structure, Tertiary; Proteins; Receptors; Receptors, Cell Surface; Residues; seedings; Signal Transduction - physiology; Signaling; Site-directed mutagenesis; Structure-function relationships; United States > US; Wisconsin

Signaling initiation by receptor-like kinases (RLKs) at the plasma membrane of plant cells often requires regulatory leucine-rich repeat (LRR) RLK proteins such as SERK or BIR proteins. The present work examined how the microbe-associated molecular pattern (MAMP) receptor FLS2 builds signaling compl...