Microbiome changes: an indicator of Parkinson’s disease?
Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of...
Saved in:
| Published in | Translational neurodegeneration Vol. 8; no. 1; pp. 38 - 9 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central
24.12.2019
BMC |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research. |
|---|---|
| AbstractList | Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research. Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research. Abstract Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research. |
| ArticleNumber | 38 |
| Author | Chen, Qian-Qian Haikal, Caroline Li, Jia-Yi |
| Author_xml | – sequence: 1 givenname: Caroline surname: Haikal fullname: Haikal, Caroline – sequence: 2 givenname: Qian-Qian surname: Chen fullname: Chen, Qian-Qian – sequence: 3 givenname: Jia-Yi orcidid: 0000-0002-7770-7376 surname: Li fullname: Li, Jia-Yi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31890161$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/6ddeb20d-5b39-4261-978b-bfa6575fc6e1$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/6ddeb20d-5b39-4261-978b-bfa6575fc6e1$$DView record from Swedish Publication Index |
| BookMark | eNqNkstu1DAUhiNUREvpA7BBkdiwCdhxfOsChCoulQbBAtZHjnMy4yFjD3YCYsdr8Ho8CZ5mqDqVQDiyHMX_-c4l__3iyAePRfGQkqeUKvEsNYQwXhGq85a8kneKk5o0stKUq6Mb78fFWUprkpcgXAh-rzhmVGlCBT0pzt85G0PrwgZLuzJ-iem8NL50vnPWjCGWoS8_mPjZ-RT8rx8_U9m5hCbhiwfF3d4MCc_252nx6fWrjxdvq8X7N5cXLxeVlYqPVSOo0I0xrRQMtWLYMKulsthownvRI-WWKkk7niUEW81ZbYiRVmmuEBk7LS5nbhfMGrbRbUz8DsE4uPoQ4hJMHJ0dEGSnLVOt7ITiDVPUMKVa3mlGZK-V2rHMzErfcDu1B7RtiKMZIGJuL9oVDBMkhKwadpNwwScQXYdtTTrgLdPQ1IJCbqWFtjeCS95bgTTnWPw1xzBt82737P_EPZ9xmbXBzqIfYy7zoPKDG-9WsAxfQeg6PyQDnuwBMXyZMI2wccniMBiPYUpQM5atkIcts_TxLek6TNHnv5tVDSVaKMaz6tHNiq5L-eOqLKCzIFsrpYj9tYQS2JkXZvNCNi_szAu71PJWjHXj1dhzU274R-Rv7D7zHg |
| CitedBy_id | crossref_primary_10_3390_genes14010226 crossref_primary_10_1016_j_anaerobe_2023_102714 crossref_primary_10_47853_FAS_2022_e11 crossref_primary_10_3389_fcimb_2021_652617 crossref_primary_10_1007_s00213_020_05605_w crossref_primary_10_1007_s00415_022_11461_9 crossref_primary_10_1038_s41551_022_00987_y crossref_primary_10_7759_cureus_19035 crossref_primary_10_1096_fj_202101051R crossref_primary_10_2174_0115733998291968240429111357 crossref_primary_10_3389_fimmu_2020_573562 crossref_primary_10_3390_brainsci10040242 crossref_primary_10_1016_j_bbi_2023_10_013 crossref_primary_10_1002_INMD_20240013 crossref_primary_10_3389_fcimb_2021_619354 crossref_primary_10_1016_j_neures_2020_04_007 crossref_primary_10_1186_s12974_020_01873_7 crossref_primary_10_2147_JIR_S333887 crossref_primary_10_1007_s00253_023_12489_1 crossref_primary_10_1021_acs_jafc_1c00923 crossref_primary_10_3748_wjg_v27_i41_7041 crossref_primary_10_1016_j_jtice_2024_105401 crossref_primary_10_17340_jkna_2021_4_4 crossref_primary_10_3390_diseases9030045 crossref_primary_10_3390_ijms24119577 crossref_primary_10_1109_TCBB_2021_3100893 crossref_primary_10_3233_JPD_212604 crossref_primary_10_3390_biom11030433 crossref_primary_10_1093_brain_awaa201 crossref_primary_10_1128_CMR_00338_20 crossref_primary_10_1038_s41598_023_40892_1 crossref_primary_10_1021_acschemneuro_0c00386 crossref_primary_10_3233_JPD_202297 crossref_primary_10_3389_fnins_2021_708587 crossref_primary_10_1177_11795735221098125 crossref_primary_10_3390_cells13090770 crossref_primary_10_1038_s41531_021_00170_1 crossref_primary_10_1038_s41598_021_86378_w crossref_primary_10_1016_j_neubiorev_2021_10_046 crossref_primary_10_1016_j_neuropharm_2021_108839 crossref_primary_10_3390_md22050193 crossref_primary_10_1007_s11064_020_03187_9 crossref_primary_10_1155_2020_8740732 crossref_primary_10_1038_s41575_022_00605_x crossref_primary_10_3389_fnins_2022_1030694 crossref_primary_10_1038_s41531_022_00359_y crossref_primary_10_1016_j_ecoenv_2022_114152 crossref_primary_10_3390_ijms22189839 crossref_primary_10_14336_AD_2022_0325 crossref_primary_10_3390_life11070698 crossref_primary_10_3389_fnut_2021_650053 crossref_primary_10_1016_j_nbd_2022_105626 crossref_primary_10_3390_ijms231810808 crossref_primary_10_1186_s13024_023_00628_1 crossref_primary_10_1016_j_mocell_2024_100161 crossref_primary_10_3389_fneur_2020_615861 crossref_primary_10_1007_s13668_024_00539_7 crossref_primary_10_3390_cells9112476 crossref_primary_10_3390_nu15040930 crossref_primary_10_1016_j_fct_2020_111946 crossref_primary_10_1038_s41522_022_00367_z crossref_primary_10_2174_1570159X18666200606233050 |
| Cites_doi | 10.3389/fnins.2019.00113 10.1186/s12974-019-1528-y 10.1016/j.cell.2016.11.018 10.1186/s40478-015-0263-6 10.1038/nrmicro3552 10.1007/s00401-014-1343-6 10.1038/srep34477 10.1038/nature11053 10.1371/journal.pone.0142164 10.1016/j.parkreldis.2019.06.003 10.1126/scitranslmed.aap9489 10.1038/nature24460 10.1016/j.parkreldis.2016.08.019 10.1371/journal.pone.0187307 10.1111/j.1574-6968.2009.01668.x 10.1093/ibd/izy190 10.1203/01.pdr.0000191137.12774.b2 10.1136/gutjnl-2015-309618 10.1002/mds.26942 10.1016/j.chom.2015.12.005 10.1038/nrmicro2259 10.1126/scitranslmed.aai7795 10.1186/s12866-016-0708-5 10.1016/j.ebiom.2014.11.004 10.1021/acschemneuro.8b00733 10.1371/journal.pone.0140194 10.3389/fnagi.2017.00441 10.1016/j.cell.2014.09.053 10.1038/nm.4517 10.1371/journal.ppat.1000886 10.1016/j.neuron.2019.05.035 10.1016/j.parkreldis.2017.02.026 10.1126/science.aaw7479 10.1128/JCM.00845-13 10.1016/j.dld.2018.09.017 10.1007/s11427-016-9001-4 10.15698/mic2018.05.628 10.1002/mds.26307 10.3748/wjg.v19.i20.2985 10.1016/j.bbi.2018.02.016 10.1038/ncomms13329 10.3748/wjg.v21.i37.10609 10.1016/j.molcel.2014.12.025 10.1016/j.cell.2014.08.006 10.1186/s13073-017-0428-y 10.1016/j.ebiom.2019.05.064 10.1371/journal.pone.0093827 10.3920/BM2017.0202 10.1007/s00702-002-0808-2 10.1136/gutjnl-2017-315542 10.1097/MIB.0000000000000914 10.1038/nmicrobiol.2016.93 10.1073/pnas.1002601107 10.1002/ana.24448 10.1111/cei.12990 10.1038/nrneurol.2015.197 10.1016/j.parkreldis.2018.05.007 10.1016/j.chom.2019.05.001 10.1002/mds.25020 10.3389/fmicb.2018.02247 10.1016/j.bbi.2018.02.005 10.1016/j.chom.2011.09.003 10.1038/s41586-019-1405-y 10.1038/ni.3780 10.1136/gutjnl-2017-315666 10.1002/mds.27203 10.1111/j.1365-2990.2007.00874.x 10.1016/j.aller.2018.12.009 10.1038/srep30891 10.1097/00005176-199901000-00007 10.1016/j.jid.2016.01.005 10.1016/j.neulet.2019.134297 10.1016/j.febslet.2014.09.039 10.1097/NMC.0000000000000373 10.1371/journal.pone.0218252 10.1073/pnas.1000087107 10.1002/mds.27105 10.1002/mds.26069 10.1007/s10517-017-3700-7 10.1038/nrmicro2403 |
| ContentType | Journal Article |
| Copyright | The Author(s). 2019. 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s). 2019 |
| Copyright_xml | – notice: The Author(s). 2019. – notice: 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s). 2019 |
| CorporateAuthor | MultiPark: Multidisciplinary research focused on Parkinson's disease Profile areas and other strong research environments Lunds universitet Institutionen för experimentell medicinsk vetenskap Lund University Neural plasticitet och reparation Strategiska forskningsområden (SFO) Department of Experimental Medical Science Faculty of Medicine Strategic research areas (SRA) Medicinska fakulteten Neural Plasticity and Repair Profilområden och andra starka forskningsmiljöer |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Strategiska forskningsområden (SFO) – name: Department of Experimental Medical Science – name: Neural plasticitet och reparation – name: Strategic research areas (SRA) – name: Lunds universitet – name: Profilområden och andra starka forskningsmiljöer – name: Lund University – name: Institutionen för experimentell medicinsk vetenskap – name: Profile areas and other strong research environments – name: Neural Plasticity and Repair – name: MultiPark: Multidisciplinary research focused on Parkinson's disease |
| DBID | AAYXX CITATION NPM 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC DOA |
| DOI | 10.1186/s40035-019-0175-7 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X7 name: Health & Medical Collection (ProQuest) url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2047-9158 |
| EndPage | 9 |
| ExternalDocumentID | oai_doaj_org_article_7d9c38b7d6854381a388b5d9307f9883 oai_portal_research_lu_se_publications_6ddeb20d_5b39_4261_978b_bfa6575fc6e1 oai_lup_lub_lu_se_6ddeb20d_5b39_4261_978b_bfa6575fc6e1 PMC6929290 31890161 10_1186_s40035_019_0175_7 |
| Genre | Journal Article Review |
| GroupedDBID | 0R~ 5VS 7X7 8FI 8FJ AAJSJ AASML AAYXX ABUWG ACGFS ACIHN ACMJI ADBBV ADRAZ ADUKV AEAQA AFKRA AHBYD AHMBA AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CITATION EBLON EBS EJD FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR IHW INH INR ITC KQ8 LGEZI LOTEE M48 NADUK NXXTH OK1 PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC RBZ RNS ROL RPM RSV SBL SOJ UKHRP -A0 2VQ 3V. 4.4 ABDBF ACRMQ ADINQ AHSBF C24 H13 IPNFZ M~E NPM RIG 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC PUEGO |
| ID | FETCH-LOGICAL-c785t-461694aab763e983e43c978ce4905f6fe15c1871d5ab70eb9532a0a7c8958ee33 |
| IEDL.DBID | M48 |
| ISSN | 2047-9158 |
| IngestDate | Wed Aug 27 01:27:31 EDT 2025 Thu Aug 21 06:41:49 EDT 2025 Thu Jul 03 04:45:27 EDT 2025 Thu Aug 21 14:31:03 EDT 2025 Thu Jul 10 23:06:49 EDT 2025 Tue Jul 01 15:23:46 EDT 2025 Thu Jan 02 22:59:30 EST 2025 Thu Apr 24 23:08:22 EDT 2025 Tue Jul 01 03:25:28 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Protein aggregation Inflammation Intestinal microbiota Parkinson’s disease Gut |
| Language | English |
| License | The Author(s). 2019. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c785t-461694aab763e983e43c978ce4905f6fe15c1871d5ab70eb9532a0a7c8958ee33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-7770-7376 |
| OpenAccessLink | https://doaj.org/article/7d9c38b7d6854381a388b5d9307f9883 |
| PMID | 31890161 |
| PQID | 2341096835 |
| PQPubID | 2040187 |
| PageCount | 9 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7d9c38b7d6854381a388b5d9307f9883 swepub_primary_oai_portal_research_lu_se_publications_6ddeb20d_5b39_4261_978b_bfa6575fc6e1 swepub_primary_oai_lup_lub_lu_se_6ddeb20d_5b39_4261_978b_bfa6575fc6e1 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6929290 proquest_miscellaneous_2331619587 proquest_journals_2341096835 pubmed_primary_31890161 crossref_primary_10_1186_s40035_019_0175_7 crossref_citationtrail_10_1186_s40035_019_0175_7 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12-24 |
| PublicationDateYYYYMMDD | 2019-12-24 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-24 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Translational neurodegeneration |
| PublicationTitleAlternate | Transl Neurodegener |
| PublicationYear | 2019 |
| Publisher | BioMed Central BMC |
| Publisher_xml | – name: BioMed Central – name: BMC |
| References | P Weimers (175_CR10) 2019; 25 KM Shannon (175_CR13) 2012; 27 JJ Goedert (175_CR24) 2014; 1 VA Petrov (175_CR45) 2017; 162 S Holmqvist (175_CR3) 2014; 128 JR Bedarf (175_CR44) 2017; 9 P Perez-Pardo (175_CR61) 2018; 9 D Knights (175_CR81) 2011; 10 JA Gilbert (175_CR22) 2018; 24 J Raisch (175_CR76) 2013; 19 DK Morales (175_CR78) 2010; 6 D Matheoud (175_CR12) 2019; 571 I Adlerberth (175_CR25) 2006; 59 VC Antharam (175_CR32) 2013; 51 M Demirci (175_CR63) 2019; 47 S Kim (175_CR4) 2019; 103 A Mulak (175_CR7) 2015; 21 F Zhu (175_CR11) 2019; 51 W Li (175_CR49) 2017; 60 T Zuo (175_CR71) 2018; 9 JM Blander (175_CR69) 2017; 18 TR Sampson (175_CR19) 2016; 167 AH Tan (175_CR58) 2018; 33 SG Chen (175_CR16) 2016; 6 E Chorell (175_CR17) 2015; 10 H Braak (175_CR1) 2003; 110 A Heintz-Buschart (175_CR40) 2018; 33 D Bhattacharyya (175_CR14) 2019; 10 JK Goodrich (175_CR28) 2014; 159 WA Walters (175_CR82) 2014; 588 L Dethlefsen (175_CR29) 2011; 108 D Vandeputte (175_CR36) 2016; 65 RL Greer (175_CR62) 2016; 7 C Hewel (175_CR75) 2019; 13 E Svensson (175_CR5) 2015; 78 D Vandeputte (175_CR37) 2017; 551 D Pietrucci (175_CR53) 2019; 65 S Nell (175_CR70) 2010; 8 MA Bauer (175_CR67) 2018; 5 T Yatsunenko (175_CR35) 2012; 486 Y Qian (175_CR42) 2018; 70 MG Dominguez-Bello (175_CR27) 2010; 107 MM Unger (175_CR51) 2016; 32 D Mihaila (175_CR60) 2019; 14 KY Hui (175_CR8) 2018; 10 T Odamaki (175_CR34) 2016; 16 S Liu (175_CR74) 2016; 19 C Kim (175_CR15) 2016; 6 F Li (175_CR52) 2019; 707 CH Hawkes (175_CR2) 2007; 33 JH Jo (175_CR66) 2016; 136 CH Lin (175_CR43) 2019; 16 S Hasegawa (175_CR48) 2015; 10 GP Donaldson (175_CR68) 2016; 14 Y Qiang (175_CR72) 2017; 189 MF Sun (175_CR73) 2018; 70 V Brochard (175_CR21) 2009; 119 A Lin (175_CR54) 2018; 53 NL Ward (175_CR31) 2016; 22 M Villumsen (175_CR9) 2019; 68 VTE Aho (175_CR55) 2019; 44 X Yang (175_CR59) 2017; 9 R An (175_CR33) 2018; 67 Y Taur (175_CR30) 2018; 10 L Klingelhoefer (175_CR6) 2015; 11 NW Palm (175_CR56) 2014; 158 E Ansaldo (175_CR64) 2019; 364 F Hopfner (175_CR47) 1667; 2017 F Scheperjans (175_CR46) 2015; 30 MM Gronlund (175_CR26) 1999; 28 EM Hill-Burns (175_CR50) 2017; 32 T Minato (175_CR57) 2017; 12 R Poretsky (175_CR65) 2014; 9 A Keshavarzian (175_CR39) 2015; 30 A Tamburrino (175_CR20) 2015; 3 BB Hsu (175_CR80) 2019; 25 ML Evans (175_CR18) 2015; 57 AB Dunn (175_CR23) 2017; 42 PAB Pereira (175_CR41) 2017; 38 ME Hibbing (175_CR77) 2010; 8 HM Roager (175_CR38) 2016; 1 ME Shirtliff (175_CR79) 2009; 299 |
| References_xml | – volume: 13 start-page: 113 year: 2019 ident: 175_CR75 publication-title: Front Neurosci doi: 10.3389/fnins.2019.00113 – volume: 16 start-page: 129 year: 2019 ident: 175_CR43 publication-title: J Neuroinflammation doi: 10.1186/s12974-019-1528-y – volume: 167 start-page: 1469 year: 2016 ident: 175_CR19 publication-title: Cell. doi: 10.1016/j.cell.2016.11.018 – volume: 3 start-page: 84 year: 2015 ident: 175_CR20 publication-title: Acta Neuropathol Commun doi: 10.1186/s40478-015-0263-6 – volume: 14 start-page: 20 year: 2016 ident: 175_CR68 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro3552 – volume: 128 start-page: 805 year: 2014 ident: 175_CR3 publication-title: Acta Neuropathol doi: 10.1007/s00401-014-1343-6 – volume: 6 start-page: 34477 year: 2016 ident: 175_CR16 publication-title: Sci Rep doi: 10.1038/srep34477 – volume: 486 start-page: 222 year: 2012 ident: 175_CR35 publication-title: Nature. doi: 10.1038/nature11053 – volume: 10 start-page: e0142164 year: 2015 ident: 175_CR48 publication-title: PLoS One doi: 10.1371/journal.pone.0142164 – volume: 65 start-page: 124 year: 2019 ident: 175_CR53 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2019.06.003 – volume: 10 start-page: eaap9489 year: 2018 ident: 175_CR30 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aap9489 – volume: 551 start-page: 507 year: 2017 ident: 175_CR37 publication-title: Nature. doi: 10.1038/nature24460 – volume: 32 start-page: 66 year: 2016 ident: 175_CR51 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2016.08.019 – volume: 12 start-page: e0187307 year: 2017 ident: 175_CR57 publication-title: PLoS One doi: 10.1371/journal.pone.0187307 – volume: 299 start-page: 1 year: 2009 ident: 175_CR79 publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.2009.01668.x – volume: 25 start-page: 111 year: 2019 ident: 175_CR10 publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izy190 – volume: 59 start-page: 96 year: 2006 ident: 175_CR25 publication-title: Pediatr Res doi: 10.1203/01.pdr.0000191137.12774.b2 – volume: 65 start-page: 57 year: 2016 ident: 175_CR36 publication-title: Gut. doi: 10.1136/gutjnl-2015-309618 – volume: 32 start-page: 739 year: 2017 ident: 175_CR50 publication-title: Mov Disord doi: 10.1002/mds.26942 – volume: 19 start-page: 32 year: 2016 ident: 175_CR74 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2015.12.005 – volume: 8 start-page: 15 year: 2010 ident: 175_CR77 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2259 – volume: 10 start-page: eaai7795 year: 2018 ident: 175_CR8 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aai7795 – volume: 16 start-page: 90 year: 2016 ident: 175_CR34 publication-title: BMC Microbiol doi: 10.1186/s12866-016-0708-5 – volume: 1 start-page: 167 year: 2014 ident: 175_CR24 publication-title: EBioMedicine. doi: 10.1016/j.ebiom.2014.11.004 – volume: 10 start-page: 2229 year: 2019 ident: 175_CR14 publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.8b00733 – volume: 10 start-page: e0140194 year: 2015 ident: 175_CR17 publication-title: PLoS One doi: 10.1371/journal.pone.0140194 – volume: 9 start-page: 441 year: 2017 ident: 175_CR59 publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2017.00441 – volume: 159 start-page: 789 year: 2014 ident: 175_CR28 publication-title: Cell. doi: 10.1016/j.cell.2014.09.053 – volume: 24 start-page: 392 year: 2018 ident: 175_CR22 publication-title: Nat Med doi: 10.1038/nm.4517 – volume: 6 start-page: e1000886 year: 2010 ident: 175_CR78 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000886 – volume: 103 start-page: 627 year: 2019 ident: 175_CR4 publication-title: Neuron. doi: 10.1016/j.neuron.2019.05.035 – volume: 38 start-page: 61 year: 2017 ident: 175_CR41 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2017.02.026 – volume: 364 start-page: 1179 year: 2019 ident: 175_CR64 publication-title: Science. doi: 10.1126/science.aaw7479 – volume: 51 start-page: 2884 year: 2013 ident: 175_CR32 publication-title: J Clin Microbiol doi: 10.1128/JCM.00845-13 – volume: 51 start-page: 38 year: 2019 ident: 175_CR11 publication-title: Dig Liver Dis doi: 10.1016/j.dld.2018.09.017 – volume: 60 start-page: 1223 year: 2017 ident: 175_CR49 publication-title: Sci China Life Sci doi: 10.1007/s11427-016-9001-4 – volume: 5 start-page: 215 year: 2018 ident: 175_CR67 publication-title: Microb Cell doi: 10.15698/mic2018.05.628 – volume: 30 start-page: 1351 year: 2015 ident: 175_CR39 publication-title: Mov Disord doi: 10.1002/mds.26307 – volume: 19 start-page: 2985 year: 2013 ident: 175_CR76 publication-title: World J Gastroenterol doi: 10.3748/wjg.v19.i20.2985 – volume: 70 start-page: 194 year: 2018 ident: 175_CR42 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2018.02.016 – volume: 7 start-page: 13329 year: 2016 ident: 175_CR62 publication-title: Nat Commun doi: 10.1038/ncomms13329 – volume: 21 start-page: 10609 year: 2015 ident: 175_CR7 publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i37.10609 – volume: 57 start-page: 445 year: 2015 ident: 175_CR18 publication-title: Mol Cell doi: 10.1016/j.molcel.2014.12.025 – volume: 158 start-page: 1000 year: 2014 ident: 175_CR56 publication-title: Cell. doi: 10.1016/j.cell.2014.08.006 – volume: 9 start-page: 39 year: 2017 ident: 175_CR44 publication-title: Genome Med doi: 10.1186/s13073-017-0428-y – volume: 44 start-page: 691 year: 2019 ident: 175_CR55 publication-title: EBioMedicine. doi: 10.1016/j.ebiom.2019.05.064 – volume: 9 start-page: e93827 year: 2014 ident: 175_CR65 publication-title: PLoS One doi: 10.1371/journal.pone.0093827 – volume: 9 start-page: 799 year: 2018 ident: 175_CR61 publication-title: Benefic Microbes doi: 10.3920/BM2017.0202 – volume: 110 start-page: 517 year: 2003 ident: 175_CR1 publication-title: J Neural Transm (Vienna) doi: 10.1007/s00702-002-0808-2 – volume: 67 start-page: 2213 year: 2018 ident: 175_CR33 publication-title: Gut. doi: 10.1136/gutjnl-2017-315542 – volume: 22 start-page: 2328 year: 2016 ident: 175_CR31 publication-title: Inflamm Bowel Dis doi: 10.1097/MIB.0000000000000914 – volume: 1 start-page: 16093 year: 2016 ident: 175_CR38 publication-title: Nat Microbiol doi: 10.1038/nmicrobiol.2016.93 – volume: 107 start-page: 11971 year: 2010 ident: 175_CR27 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1002601107 – volume: 78 start-page: 522 year: 2015 ident: 175_CR5 publication-title: Ann Neurol doi: 10.1002/ana.24448 – volume: 189 start-page: 290 year: 2017 ident: 175_CR72 publication-title: Clin Exp Immunol doi: 10.1111/cei.12990 – volume: 11 start-page: 625 year: 2015 ident: 175_CR6 publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2015.197 – volume: 53 start-page: 82 year: 2018 ident: 175_CR54 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2018.05.007 – volume: 25 start-page: 803 year: 2019 ident: 175_CR80 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2019.05.001 – volume: 27 start-page: 716 year: 2012 ident: 175_CR13 publication-title: Mov Disord doi: 10.1002/mds.25020 – volume: 9 start-page: 2247 year: 2018 ident: 175_CR71 publication-title: Front Microbiol doi: 10.3389/fmicb.2018.02247 – volume: 70 start-page: 48 year: 2018 ident: 175_CR73 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2018.02.005 – volume: 10 start-page: 292 year: 2011 ident: 175_CR81 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2011.09.003 – volume: 571 start-page: 565 year: 2019 ident: 175_CR12 publication-title: Nature. doi: 10.1038/s41586-019-1405-y – volume: 18 start-page: 851 year: 2017 ident: 175_CR69 publication-title: Nat Immunol doi: 10.1038/ni.3780 – volume: 68 start-page: 18 year: 2019 ident: 175_CR9 publication-title: Gut. doi: 10.1136/gutjnl-2017-315666 – volume: 33 start-page: 174 year: 2018 ident: 175_CR58 publication-title: Mov Disord doi: 10.1002/mds.27203 – volume: 33 start-page: 599 year: 2007 ident: 175_CR2 publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2007.00874.x – volume: 47 start-page: 365 year: 2019 ident: 175_CR63 publication-title: Allergol Immunopathol (Madr) doi: 10.1016/j.aller.2018.12.009 – volume: 6 start-page: 30891 year: 2016 ident: 175_CR15 publication-title: Sci Rep doi: 10.1038/srep30891 – volume: 28 start-page: 19 year: 1999 ident: 175_CR26 publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/00005176-199901000-00007 – volume: 2017 start-page: 41 year: 1667 ident: 175_CR47 publication-title: Brain Res – volume: 136 start-page: e23 year: 2016 ident: 175_CR66 publication-title: J Invest Dermatol doi: 10.1016/j.jid.2016.01.005 – volume: 707 start-page: 134297 year: 2019 ident: 175_CR52 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2019.134297 – volume: 588 start-page: 4223 year: 2014 ident: 175_CR82 publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.09.039 – volume: 42 start-page: 318 year: 2017 ident: 175_CR23 publication-title: MCN Am J Matern Child Nurs doi: 10.1097/NMC.0000000000000373 – volume: 14 start-page: e0218252 year: 2019 ident: 175_CR60 publication-title: PLoS One doi: 10.1371/journal.pone.0218252 – volume: 119 start-page: 182 year: 2009 ident: 175_CR21 publication-title: J Clin Invest – volume: 108 start-page: 4554 issue: Suppl 1 year: 2011 ident: 175_CR29 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1000087107 – volume: 33 start-page: 88 year: 2018 ident: 175_CR40 publication-title: Mov Disord doi: 10.1002/mds.27105 – volume: 30 start-page: 350 year: 2015 ident: 175_CR46 publication-title: Mov Disord doi: 10.1002/mds.26069 – volume: 162 start-page: 734 year: 2017 ident: 175_CR45 publication-title: Bull Exp Biol Med doi: 10.1007/s10517-017-3700-7 – volume: 8 start-page: 564 year: 2010 ident: 175_CR70 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2403 |
| SSID | ssj0000605665 |
| Score | 2.4132674 |
| SecondaryResourceType | review_article |
| Snippet | Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of... Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of... Abstract Parkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the... |
| SourceID | doaj swepub pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 38 |
| SubjectTerms | Antibiotics Biopsy Cesarean section Clinical Medicine Disease Feces Gut Inflammation Inflammatory bowel disease Intestinal microbiota Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Microbiota Neurologi Neurology Parkinson's disease Pathology Protein aggregation Review Studies |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1PaxUxEA_Sg3gR69-1VVbwJCzdTTb_ehGVliI8TxaKl5BkE1qo-x7ue3e_hl_PT-JMkj7eYlEPHvaymw3DzCQzv0zyCyGvWfRUB0kbSB5401PcBCC4bESIjnvunbK4Drn4JM7O-48X_GLnqi_cE5bpgbPijuSgPVNODkJxpKOyTCnHBw2-GbVSiecTYt4OmMpzMAR2wUsZs1PiaOoTO2OLZ3YgZDZyFogSX_9tSebveyVnjKIpCp0-IPdL-li_y2LvkzthfEjuLkqB_BE5XlxlZqWvoc5neqfj2o41VqY94ut6GWs86ZwOff38_mOqS4nm7WNyfnry-cNZU65HaLxUfN30ohO6t9bBFBG0YqFnHjChD71ueRQxdNx3gIcGDk3a4DRn1LZWeqW5CoGxJ2RvXI7hGakVxKihU1qJgSNAUTQqG1vtuQugf1qR9kZXxhfucLzC4tokDKGEyeo1oF6D6jWyIm-2v6wyccafGr9HA2wbIud1egGeYIonmL95QkUOb8xnykCcDIUoDSgN8syKvNp-hiGEdRE7huUG2zDIe0EpIMfTbO2tJDDlacyKKyJnfjATdf5lvLpMNN0CMk-q24qcZI-Z_XK9WcHj4DFTMAKCjKPtYLhj2iCqNWBJZ1y0WBiLXgSQ4Mst_WSQZgoz1GXpb7Wz5PtPnT__HwY4IPcojq-ONrQ_JHvrb5vwAlK2tXuZRucvreY85A priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9UwFA86QXwRv-2cUsEnoaxNmq-9DJWNIVyfHFx8CUmauMHWXtd73_039u_5l3hOm1stjuFDX9o0HM7J-U5-IeQdi57qIGkBwQMvaoqbAASXhQjRcc-9UxbrkIsv4uS0_rzky1Rw69O2yq1NHAx103mske9TMLcQbkPAcLj6UeCtUdhdTVdo3CX3ELoMt3TJpZxqLCXE6kLw1MyslNjv6wGjscSTO-A4CzlzRwNq_02h5r87Jme4ooMvOn5EHqYgMv8wSv0xuRPaJ-T-IrXJn5KDxfmIr3QZ8vFkb3-Q2zbH_rTHLDvvYo7nnYejX79-Xvd5atQcPiOnx0dfP50U6ZKEwkvF10UtKqFrax0YiqAVCzXzkBn6UOuSRxFDxX0FWVHDYUgZnOaM2tJKr4BfITD2nOy0XRteklyBp2oqpZVoOKYpikZlY6k9d6HRnmak3PLK-IQgjhdZXJghk1DCjOw1wF6D7DUyI--nX1YjfMZtgz-iAKaBiHw9vOiuvpukSEYCJUw52QjFEZ7MMqUcbzTYqqiVYhnZ24rPJHXszZ_Fk5G302dQJOyO2DZ0GxzDIPoFpgAdL0ZpT5SA4dMYG2dEztbBjNT5l_b8bADrFhB_Ul1m5GhcMbNfLjYreBw8pg9GgKtxtGwMd0wbzG0NSNIZFy22x6IXASj4dsM8Y6pmEj7UWZpv9Vfh978m372dd6_IA4qaU9GC1ntkZ321Ca8hJFu7N4Pe_Qa7VTWF priority: 102 providerName: ProQuest |
| Title | Microbiome changes: an indicator of Parkinson’s disease? |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31890161 https://www.proquest.com/docview/2341096835 https://www.proquest.com/docview/2331619587 https://pubmed.ncbi.nlm.nih.gov/PMC6929290 https://lup.lub.lu.se/record/6ddeb20d-5b39-4261-978b-bfa6575fc6e1 oai:portal.research.lu.se:publications/6ddeb20d-5b39-4261-978b-bfa6575fc6e1 https://doaj.org/article/7d9c38b7d6854381a388b5d9307f9883 |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1ti9QwEA73AuIX8d3quVQQBKHaJs2bIMee7HEs7CHqwuKX0KTJ3cHaXbe7oP_eSZpdLC5yH0qhTcMwyWSeyTTPIPSaOIOl5TgD8ECzEvufABjlGbNOU0ONFpXfh5xcsotpOZ7R2QHalreKCmz3hna-ntR0NX_36-fvUzD4j8HgBXvfloF4MffHccAbZvwQHYNj4t5OJxHtdwszePtQXBJ7fgJZUBHznHt76XmqQOi_D4X--zNlj3I0uKnz--hexJfpsJsQD9CBbR6iO5OYQX-ExOSmo176YdPu0G_7Ia2a1KeujQ_A04VL_VHocCrsTZvGDM7pYzQ9H337dJHF6gmZ4YKus5IVTJZVpWEFsVIQWxIDIaOxpcypY84W1BQQLtUUmuRWS0pwlVfcCEmFtYQ8QUfNorHPUCrAhdWFkILV1McvAjtRuVwaqm0tDU5QvtWUMpFa3Fe4mKsQYgimOuUqUK7yylU8QW93nyw7Xo3_NT7z6t819JTY4cFidaWihSkOkhChec0E9bxlFRFC01rCIuakECRBJ9vBU9tppjA4cQjiAIYm6NXuNViYT5tUjV1sfBsCsBiUAnI87cZ6JwmsiNKD5gTx3izoidp_09xcBxZvBsAUyzxBo26-9D6Zb5ZwabhUaxUDH6RxXiuqiVQ-6FUwklppV_m8mTPMggTf9_TTmY-KxFHXsb_lXzvCt-r8-S2U8wLdxd54Cpzh8gQdrVcb-xIA21oP0CGf8QE6Hg7HX8dwPxtdfv4yCNsfg2CifwBfXT-U |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3batRA9FBaUF_Eu9GqEfRFCE0mmclMQYrVLVvbXURaKL6MmcnEFmp2bXYR3_wNf8KP8ks8J5ldDZbiSx_ykkyG4dwvc84BeJZWlimXswiNBx5ljC4BCJ5HwlWGW26NLCgOORqL4WH29ogfrcDPRS0MXatcyMRWUJcTSzHyDYbiFs1tNBi2pl8imhpF2dXFCI2OLPbct6_osjUvd98gfp8ztjM4eD2M_FSByOaSz6JMJEJlRWGQs5ySqctSi66UdZmKeSUql3CboBtRclwSO6N4yoq4yK1UXDpHAVAU-WtZiq7MKqxtD8bv3i-jOjF6B0Jwnz5NpNhosrYrZEy1Qqiqo7ynANs5AecZt__e0ex1Mm21384NuO7N1vBVR2c3YcXVt-DKyCfmb8Pm6KTr6PTZhV0tcbMZFnVIGXFLfn04qUKqsG6LzX59_9GEPjW0dQcOLwWAd2G1ntTuPoQSdWOZSCVFyckxkqySRRUry40rlWUBxAtYaet7ltPojFPd-i5S6A68GsGrCbw6D-DF8pdp17DjosXbhIDlQuq13b6YnH3SnnV1jidJpclLITk1RCtSKQ0vFUrHSkmZBrC-QJ_2AqDRf8g1gKfLz8i6lI8pajeZ05oU7W0ECp7jXoft5UlQ1CqyxgPIe3TQO2r_S31y3LYHF2jxMhUHMOgopvfL6XyKj8FHN04LVG6GxaXmJlWavGmNmDTaVAUl5CorHJ7gwzn7dM6h9h2pjv1-079Czf-1-YOLYfcErg4PRvt6f3e89xCuMeKihEUsW4fV2dncPUKDcGYeey4M4eNlM_5vULRzEg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microbiome+changes%3A+an+indicator+of+Parkinson%27s+disease%3F&rft.jtitle=Translational+neurodegeneration&rft.au=Haikal%2C+Caroline&rft.au=Chen%2C+Qian-Qian&rft.au=Li%2C+Jia-Yi&rft.date=2019-12-24&rft.issn=2047-9158&rft.eissn=2047-9158&rft.volume=8&rft.spage=38&rft_id=info:doi/10.1186%2Fs40035-019-0175-7&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2047-9158&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2047-9158&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2047-9158&client=summon |