The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort

• Published in: Journal of allergy and clinical immunology Vol. 130; no. 4; pp. 912 - 917
• Main Authors: Margolis, David J., Apter, Andrea J., Gupta, Jayanta, Hoffstad, Ole, Papadopoulos, Maryte, Campbell, Linda E., Sandilands, Aileen, McLean, W.H. Irwin, Rebbeck, Tim R., Mitra, Nandita
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2012; Elsevier; Elsevier Limited
• Subjects: African Americans; Allergic diseases; Allergies; Allergy and Immunology; ancestry; Asthma; Atopic dermatitis; atopy; Biological and medical sciences; Child, Preschool; Children; Cohort Studies; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - genetics; drug therapy; epidemiology; Female; Filaggrin; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes; genetic epidemiology; Humans; Immunopathology; Infant; Intermediate Filament Proteins - genetics; Longitudinal Studies; Male; Medical sciences; Medical treatment; Mutation; odds ratio; Pathogenesis; Polymorphism, Single Nucleotide; Population; pruritus; risk; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin allergic diseases. Stinging insect allergies; Skin diseases; Studies; United States; United States; North America; America; United States > US; FLG; epidemiology; AD; OR; Atopic dermatitis; AIM; PEER; atopy; ALSPAC; FLG null; filaggrin; genetic epidemiology; Pediatric Eczema Elective Registry; Filaggrin loss of function; Avon Longitudinal Study of Parents and Children; Ancestry informative marker; Odds ratio; Allergy; Immunopathology; Skin disease; Filaggrin; Epidemiology; Atopy; Persistence; Immunology; Epidemiologic genetics; Cohort study; Mutation

Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have been associated with an increased risk of AD. We sought to evaluate the effect of individual FLG null mutations on the persistence of AD...