Structure of the F-actin–tropomyosin complex

• Published in: Nature (London) Vol. 519; no. 7541; pp. 114 - 117
• Main Authors: von der Ecken, Julian, Müller, Mirco, Lehman, William, Manstein, Dietmar J., Penczek, Pawel A., Raunser, Stefan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.03.2015; Nature Publishing Group
• Subjects: 101/28; 631/535/1258/1259; 631/80/128/1276; Actin; Actins - chemistry; Actins - genetics; Actins - metabolism; Adenosine Diphosphate - metabolism; Analysis; Animals; Cryoelectron Microscopy; Cytoskeleton; Genetic aspects; Hearing loss; Humanities and Social Sciences; letter; Magnesium - metabolism; Mice; Models, Molecular; Molecular structure; multidisciplinary; Muscle proteins; Mutation; Mutation - genetics; Myosin; Polymerization; Protein Conformation; Proteins; Rabbits; Science; Static Electricity; Tropomyosin - chemistry; Tropomyosin - genetics; Tropomyosin - metabolism; United States

Electron cryomicroscopy reveals the three-dimensional structure of F-actin at a resolution of 3.7 Å in complex with tropomyosin at a resolution of 6.5 Å; the stabilizing interactions and the effects of disease-causing mutants are also investigated. The interaction of F-actin and tropomyosin (Rausner...