Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells

• Published in: PloS one Vol. 4; no. 11; p. e8065
• Main Authors: Ji, Junfeng, Werbowetski-Ogilvie, Tamra E, Zhong, Bonan, Hong, Seok-Ho, Bhatia, Mickie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.11.2009; Public Library of Science (PLoS)
• Subjects: Apoptosis; Bifurcations; Cancer; Cancer research; Cell Biology/Developmental Molecular Mechanisms; Cell Differentiation; Cell Line; Cell Line, Transformed; Cell self-renewal; Cell survival; Developmental Biology/Stem Cells; DNA binding proteins; Embryos; Flow Cytometry - methods; Gene expression; Glycoproteins; Green Fluorescent Proteins - metabolism; Homeodomain Proteins - metabolism; Humans; Hypersensitivity; Jargon; Lentivirus - metabolism; Medical research; Models, Biological; Nanog Homeobox Protein; Neoplastic Stem Cells - cytology; Oct-4 protein; Octamer Transcription Factor-3 - metabolism; Oncology; Pluripotency; Pluripotent Stem Cells - cytology; Rodents; Stem cells; Survival; Teratoma - metabolism; Transcription factors; Transcription Factors - metabolism; Transgenic animals; Tumors; Ontario Canada; Canada

Cancer and normal stem cells (SCs) share proliferative properties of self-renewal and expression of key transcription factors (TFs). Despite similar TF identities, the functional role of specific TFs responsible for retaining SC state has yet to be examined in cancer. Here, we compare the role of Oc...