Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines - Seo, Yohan; Park, Jinhong; Kim, Minseo; Lee, Ho K.; Kim, Jin-Hee; Jeong, Jin-Hyun; Namkung, Wan (PloS one, 2015)
Keywords: Alzheimer's disease; Alzheimers disease; Animals; Anoctamin-1; Antineoplastic Agents - pharmacology; Antioxidants - pharmacology; Apoptosis; Biological Products - pharmacology; Breast cancer; Calcium; Calcium (intracellular); Calcium chloride; Calcium Signaling; Calcium signalling; Cancer; Cell Line, Tumor; Cell migration; Cell Proliferation; Chloride channels (calcium-gated); Chloride Channels - antagonists & inhibitors; Chloride Channels - metabolism; Coenzyme Q10; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; Cytotoxicity; Enzymes; Esophagus; Gene expression; Humans; Inhibition; Inhibitors; Intracellular signalling; Kinases; Metabolism; Metastasis; Miconazole; Miconazole - pharmacology; Naphthoquinones - pharmacology; Natural products; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Pancreatic cancer; Penicillin; Pharmaceutical sciences; Pharmacy; Plumbagin; Prostate cancer; Rats; Rats, Inbred F344; Screening; Signal transduction; Smooth muscle; Toxicity; Tumor cell lines; Tumors; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology