Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence

• Published in: PloS one Vol. 13; no. 11; p. e0207694
• Main Authors: Cole, Shannon L, Robinson, Mike J F, Berridge, Kent C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.11.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Animal behavior; Animals; Biology and Life Sciences; Brain; Cocaine; Dopamine; Dopamine D1 receptors; Dopamine D2 receptors; Dopamine receptors; Engineering and Technology; Excitation; Female; Females; Fiber optics; Food; Hypotheses; Internet; Laboratory animals; Lasers; Male; Males; Medicine and Health Sciences; Membrane proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motivation; Neurons; Neurosciences; Nucleus accumbens; Nucleus Accumbens - metabolism; Nucleus Accumbens - pathology; Optical fibers; Optogenetics; Phenols (Class of compounds); Photomicrography; Receptors; Receptors, Dopamine D1 - genetics; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; Reinforcement; Research and Analysis Methods; Rodents; Self stimulation; Social Sciences; Spiny neurons; Subpopulations; Transgenic animals; Viruses; United States > US

The nucleus accumbens (NAc) contains multiple subpopulations of medium spiny neurons (MSNs). One subpopulation expresses D1-type dopamine receptors, another expresses D2-type receptors, and a third expresses both. The relative roles in NAc of D1 neurons versus D2 neurons in appetitive motivation wer...