Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

• Published in: PLoS biology Vol. 18; no. 6; p. e3000644
• Main Authors: Boulouis, Caroline, Sia, Wan Rong, Gulam, Muhammad Yaaseen, Teo, Jocelyn Qi Min, Png, Yi Tian, Phan, Thanh Kha, Mak, Jeffrey Y W, Fairlie, David P, Poon, Ivan K H, Koh, Tse Hsien, Bergman, Peter, Lim, Chwee Ming, Wang, Lin-Fa, Kwa, Andrea Lay Hoon, Sandberg, Johan K, Leeansyah, Edwin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2020; Public Library of Science (PLoS)
• Subjects: Analysis; Anti-Infective Agents - pharmacology; Antibiotic resistance; Antibiotics; Antigens; Antigens, Differentiation, T-Lymphocyte - metabolism; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Apoptosis; Bacteria; Bacterial infections; Bacterial Load - drug effects; Bactericidal activity; Biology; Biology and Life Sciences; Carbapenems; Carbapenems - pharmacology; Clinical isolates; Cytokines; Cytotoxicity, Immunologic - drug effects; Dosage and administration; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Bacterial - drug effects; E coli; Escherichia coli; Escherichia coli - drug effects; Flow cytometry; Funding; Granzyme B; Granzymes - metabolism; HeLa Cells; Hospitals; Humans; Infections; Infectious diseases; Inflammation; Kinetics; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Medical schools; Medicin och hälsovetenskap; Medicine; Medicine and Health Sciences; Microorganisms; Mucosa; Mucosal-Associated Invariant T Cells - immunology; Multidrug resistance; Otolaryngology; Pathogens; Permeability; Pharmacy; Pore formation; Proteins; R&D; Research & development; Research and analysis methods; Riboflavin; Serine; Serine proteinase; Surgery; Synergism; T cell receptors; T cells; T-cell receptor; Vitamin B; Sweden; Singapore; Queensland Australia; Australia

Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanisms responsible for MAIT cell antimicrobial activity are not fu...