A Novel Animal Model of Hearing Loss Caused by Acute Endoplasmic Reticulum Stress in the Cochlea

• Published in: Journal of Pharmacological Sciences Vol. 118; no. 3; pp. 363 - 372
• Main Authors: Fujinami, Yoshiaki, Mutai, Hideki, Mizutari, Kunio, Nakagawa, Susumu, Matsunaga, Tatsuo
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 2012; The Japanese Pharmacological Society; Elsevier
• Subjects: Activating Transcription Factor 4 - genetics; animal model; Animals; Cochlea - pathology; Cochlea - physiopathology; Disease Models, Animal; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - physiology; Gene Expression Regulation; hearing loss; Hearing Loss - genetics; Hearing Loss - pathology; Hearing Loss - physiopathology; Male; Membrane Glycoproteins - genetics; Rats; Rats, Sprague-Dawley; Transcription Factor CHOP - genetics; tunicamycin; Tunicamycin - administration & dosage; hearing loss; animal model; endoplasmic reticulum stress; tunicamycin

Many stimuli such as ischemia, hypoxia, heat shock, amino acid starvation, and gene mutation, exhibit a cellular response called endoplasmic reticulum (ER) stress. ER stress induces expression of a series of genes, leading to cell survival or apoptosis. Previously, we found that in an animal model o...