Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

• Published in: PLoS pathogens Vol. 9; no. 11; p. e1003773
• Main Authors: Crotta, Stefania, Davidson, Sophia, Mahlakoiv, Tanel, Desmet, Christophe J., Buckwalter, Matthew R., Albert, Matthew L., Staeheli, Peter, Wack, Andreas
• Format: Journal Article Web Resource
• Language: English
• Published: United States Public Library of Science 01.11.2013; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Signal Transducing - metabolism; Airway (Medicine); Animals; Cytokines; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial Cells - virology; Experiments; Genes; Genetic aspects; Genetic transcription; Genomes; Genomics; Health aspects; Host-parasite relationships; Human health sciences; Immunologie & maladie infectieuse; Immunology; Immunology & infectious disease; Influenza; Influenza A virus - genetics; Influenza A virus - immunology; Influenza A virus - metabolism; Interferon; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-3 - immunology; Interferon Regulatory Factor-3 - metabolism; Interferon Regulatory Factor-7 - genetics; Interferon Regulatory Factor-7 - immunology; Interferon Regulatory Factor-7 - metabolism; Interferon Type I - genetics; Interferon Type I - immunology; Interferon Type I - metabolism; Interleukins - genetics; Interleukins - immunology; Interleukins - metabolism; Kinases; Life Sciences; Membrane Proteins - genetics; Membrane Proteins - immunology; Membrane Proteins - metabolism; Mice; Mice, Knockout; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - immunology; Nerve Tissue Proteins - metabolism; Orthomyxoviridae Infections - genetics; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - metabolism; Physiological aspects; Receptors, Cell Surface; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory Mucosa - virology; Rodents; Sciences de la santé humaine; Viral infections; Germany; Influenza A virus; Interferons; Microarrays; Influenza; Genetic interference; Gene expression; Viral replication; Enzyme-linked immunoassays

Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IFN stimulated genes (ISGs) with antiviral function....